I am about to conduct a meta-regression analysis to fit some age-related changes. Since the GAMLSS approach is highly suggested in the normal regression of such data, I want to apply GAMLSS to my study. However, I could not find avalible packages to achieve this. Could any one help me? If indeed there's no available packages, is there any way to achieve that easily? I cannot simply apply the meta-regression with the normal GAMLSS method, since the latter does not take the variance of studies into account. Any suggestions are appreciated.

  • $\begingroup$ I cannot directly answer your question since I am not familiar enough with the gamlss package, but you can model non-linear relationships, for example using splines, using the metafor package; see here for some examples: metafor-project.org/doku.php/tips:non_linear_meta_regression $\endgroup$
    – Wolfgang
    Aug 23, 2022 at 15:56
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    $\begingroup$ Thanks a lot for this suggestion! The spline regression is indeed a good alternative, if GAMLSS cannot be achieved. I'll see if it works good enough in my data. $\endgroup$
    – Jack Yang
    Aug 24, 2022 at 3:24

1 Answer 1


There is a meta-analysis example using gamlss on pages 341-345 (in the Chapter 10: Random effects) of

'Flexible Regression and Smoothing: Using GAMLSS in R’ M. D. Stasinopoulos, R. A. Rigby, G. Z. Heller, V. Voudouris and F. De Bastiani. Chapman and Hall/CRC, Boca Raton, 2017


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