Let $X_1, \cdots, X_n$ be a sample from the $N(\mu, \sigma^2)$ density, where $\mu, \sigma^2$ are unknown. I want to find a lower bound $L_n$ which is valid for all sample-sizes $n$ for the variance of unbiased estimators of $\theta = \mu/\sigma$.
I know that for one-dimensional parameters the Cramer-Rao lower bound for unbiased estimators is given by $\frac{1}{I(\theta)}$, where $I(\theta)$ is the fisher information. Since $\mu, \sigma^2$ are unknown the Fisher information becomes a $2\times 2$ matrix. So how can the Fisher information matrix help me to find the Cramer-Rao lower bound?
Any hints will be appreciated.