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I have two groups of samples with a proportion of mutations in each sample being a particular type (the proportions are represented as a fraction of 1). How to I check if that type of mutation is significantly likelier to happen in one group over the other?

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    $\begingroup$ You could use a $\chi^2$ test for proportions. $\endgroup$ – user25658 Sep 7 '13 at 2:09
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    $\begingroup$ See stats.stackexchange.com/questions/2391/… $\endgroup$ – Gala Sep 7 '13 at 5:06
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    $\begingroup$ If you want to be able to consider both one- and two- tailed tests, what about a two-sample proportions test? $\endgroup$ – Glen_b Sep 7 '13 at 7:16
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Partially answered in comments:

You could use a χ2 test for proportions. – user25658 If you want to be able to consider both one- and two- tailed tests, what about a two-sample proportions test? – Glen_b

See also What is the relationship between a chi squared test and test of equal proportions?

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