Given that $Y_{1}$ and $Y_{2}$ are independent, we have that
$$
\left[\array{Y_{11} \\ Y_{12} \\ Y_{13} \\ Y_{21} \\ Y_{22}}\right] \sim MVN\left(\left[\array{2\\2\\2\\3\\4}\right],\left[\array{3 & 1 & 0 & 0 & 0\\1 & 2 & 0 & 0 &0\\0&0&3&0&0\\0&0&0&4&2\\0&0&0&2&4}\right]\right)
$$
Let
$$
\begin{array}{rcl}X_1 & = & Y_{11}-Y_{13}+Y_{22}\\
X_2 & = & Y_{21}-Y_{12}\end{array}
$$
As $Y_{11},Y_{12},Y_{13},Y_{21},Y_{22}$ are jointly normal, the linear combinations $Y_{11}-Y_{13}+Y_{22}$ and $Y_{21}-Y_{12}$ are normally distributed. It also follows that as any linear combination of $X_{1}$ and $X_{2}$ is a linear combination of $Y_{11},Y_{12},Y_{13},Y_{21},Y_{22}$ so must $X_{1}$ and $X_{2}$ be jointly normal.
All that remains is to determine the mean and covariance of $X_{1}$ and $X_{2}$. Given the linearity of expectations, the mean is trivial to calculate:
$$
\begin{array}{rcl}
E[X_1] &=& E[Y_{11} - Y_{13} + Y_{22}]\\ &=& E[Y_{11}] - E[Y_{13}] + E[Y_{22}]\\
E[X_2] &=& E[Y_{21} - Y_{12}]\\ &=& E[Y_{21}] - E[Y_{12}]
\end{array}
$$
The covariance is equally straightforward yet tedious:
$$
\begin{array}{rcl}
Cov[X_1,X_1] &=& Cov[Y_{11},Y_{11}] + 2 \times Cov[Y_{11},-Y_{13}+Y_{22}] + Cov[-Y_{13}+Y_{22},-Y_{13}+Y_{22}]\\
&=& Cov[Y_{11},Y_{11}] - 2 \times Cov[Y_{11},Y_{13}] + 2 \times Cov[Y_{11},Y_{22}] + Cov[Y_{13},Y_{13}] - 2 \times Cov[Y_{13},Y_{22}] + Cov[Y_{22},Y_{22}]\\\\
Cov[X_2,X_2] &=& Cov[Y_{21},Y_{21}] - 2 \times Cov[Y_{12},Y_{21}] + Cov[Y_{12},Y_{12}]\\\\
Cov[X_1,X_2] &=& Cov[Y_{11},Y_{21}-Y_{12}] + Cov[-Y_{13}+Y_{22},Y_{21}-Y_{12}]\\
&=& Cov[Y_{11},Y_{21}] - Cov[Y_{11},Y_{12}] - Cov[Y_{13},Y_{21}] + Cov[Y_{13},Y_{12}] + Cov[Y_{22},Y_{21}] - Cov[Y_{22},Y_{12}]
\end{array}
$$
Fortunately many of these terms are zero.
Given the tedious nature of the calculations you can do a simple Monte Carlo simulation to check your answers. Here is some R
code for achieving that:
# Include MASS library for mvrnorm for generating multivariate normally distributed samples
library(MASS)
generateSamples <- function(N)
{
# Generate N samples from Y1 and Y2 with the given mean vectors and covariance matrices
Y1 <- mvrnorm(mu=rep(2,3),Sigma=matrix(c(3,1,0,1,2,0,0,0,3),nrow=3,ncol=3),n=N)
Y2 <- mvrnorm(mu=c(3,4),Sigma=matrix(c(4,2,2,4),nrow=2,ncol=2),n=N)
# Calculate X1 and X2
X1 <- Y1[,1] - Y1[,3] + Y2[,2]
X2 <- Y2[,1] - Y1[,2]
cbind(X1,X2)
}
# Generate 100000 samples from X1 and X2
mySample <- generateSamples(100000)
# Empirical mean vector
mu <- colMeans(mySample)
# Empirical covariance matrix
Sigma <- cov(mySample,mySample)