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How to calculate sample size needed for GWAS for a given MAF, power, $p$-value and frequency of the disease ?

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    $\begingroup$ I assume GWAS is a genome-wide association study, but what is MAF? $\endgroup$ – Simon Byrne Mar 28 '11 at 13:36
  • $\begingroup$ @Simon MAF stands for minor allele frequency. $\endgroup$ – chl Mar 28 '11 at 14:10
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Haven't tried it myself, but you might like to try the GWApower R package. See Spencer et al. 2009.

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