How to calculate sample size needed for GWAS for a given MAF, power, $p$-value and frequency of the disease ?
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1$\begingroup$ I assume GWAS is a genome-wide association study, but what is MAF? $\endgroup$ – Simon Byrne Mar 28 '11 at 13:36
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$\begingroup$ @Simon MAF stands for minor allele frequency. $\endgroup$ – chl Mar 28 '11 at 14:10
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Haven't tried it myself, but you might like to try the GWApower R package. See Spencer et al. 2009.
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$\begingroup$ (+1) I also have this one in my list, Power analysis for genome-wide association studies. $\endgroup$ – chl Mar 28 '11 at 21:12
