# A Conditional Probability Problem

This is a biological problem, however the problem requires a statistical solution, so therefore I'll keep it as abstract as possible in order for statisticians to be also able to contemplate it - I'm also only partially sure it requires a conditional probability solution.

Basically, I have a bunch of 'miRNAs' and these target certain proteins:

miRNA1 ----> protein1
miRNA1 ----> protein2
miRNA1 ----> protein3
miRNA1 ----> protein4
miRNA1 ----> protein5

miRNA2 ----> protein3
miRNA2 ----> protein4
miRNA2 ----> protein5


There are many different miRNAs that target many different proteins.

However, up to two different miRNAs come from the same 'area'.

Therefore I want to determine whether given that these miRNAs come from the same area: are their gene targets more similar?

Any help on this matter would be extremely useful!

• Do you have a specific method in mind for measuring similarity between two sets of gene targets, or is that part of the question? Mar 23, 2014 at 13:55
• That really is part of the question: I don't know how you'd go about measuring their similarity. What methods are there for measuring how similar these targets are? Mar 23, 2014 at 17:10