fisher information matrix of Negative Binomial distribution can anyone show me how to find the Fisher information matrix for negative binomial distribution, if I parameterize the Negative Binomial distribution using parameters mean and size. 
 A: The negative binomial distribition parametrized by mean and size can be given by
$$ \DeclareMathOperator{\P}{\mathbb{P}}
   \P (X=k) = \binom{k+m-1}{k}\left( \frac{m}{m+\mu} \right)^m \left( \frac{\mu}{m+\mu} \right)^k   
$$
for the outcome $k$ a nonnegative integer, and $\mu>0$ the mean, $m>0$ the size. I will do the calculations by maple.
The Fisher information matrix (of size $2\times 2$) has components 
$I_{\mu\mu}, I_{\mu m} \text{ and } I_{m m}$ given by
$$ \DeclareMathOperator{\E}{\mathbb{E}}
  I_{ij}=-\E\left\{ \frac{\partial^2}{\partial \theta_i \partial\theta_j}\log f(X;\theta)|\theta \right\}
$$ where here $\theta=(\mu, m)$. Then we (maple code at the end of post)  find 
$$
  I_{\mu\mu}=\frac{m}{(m+\mu)\mu}
$$
The diagonal term is simplest, it reduces to zero! That is the beauty of the mean parametrization
$$
I_{\mu m}=0
$$ showing that $\mu$ and $m$ are orthogonal parameters.
For the last term, the result will involve a trigamma function written $\Psi(1,\cdot)$ (second derivative of log of gamma function) and result will be a somewhat complex infinite series, which must be evaluated numerically:
$$
I_{mm}=\sum_{k=0}^\infty \binom{k+m-1}{k}\left\{ -m^{m-1}\mu^k (m+\mu)^{-m-2-k} \left( m(m+\mu)^2 \Psi(1,k+m) -m(m+\mu)^2 \Psi(1,m) +mk+\mu^2 \right) 
\right\}
$$
A concise form can be derived either by simplifying the expression that Maple given above:
\begin{align*}
I_{mm} =& -\sum_{k=0}^\infty\binom{k+m-1}{k}\left(\frac{m}{m+\mu}\right)^m \left(\frac{\mu}{m+\mu}\right)^k\{\frac{1}{(m+\mu)^2m}\left(m(m+\mu)^2\Psi(1,k+m)-m(m+\mu)^2\Psi(1,m)+m k+\mu^2\right)\}\\
=&  -\mathbb{E}\left(\frac{1}{(m+\mu)^2m}\left(m(m+\mu)^2\Psi(1,X+m)-m(m+\mu)^2\Psi(1,m)+m X+\mu^2\right)\right)\\
=& -\mathbb{E}\left(\frac{1}{(m+\mu)^2m}\{m(m+\mu)^2(\Psi(1,X+m) - \Psi(1,m))+m X +\mu^2\}\right)\\
=& -\mathbb{E}\left(\Psi(1,X+m) - \Psi(1,m)\right) - \frac{\mu}{m(m+\mu)}
\end{align*}
where $X$ follows negative binomial distribution with mean $\mu$ and size $m$.
Or by definition of Fisher information 
\begin{align*}
I_{mm} =& - \mathbb{E}\frac{\partial^2}{\partial  m^2}\ln \mathbb{P}(X;\mu,m)  \\
=& - \mathbb{E}\frac{\partial}{\partial  m} \{\Psi(X+ m) - \Psi( m) + \ln\frac{ m}{ m+\mu} + \frac{\mu -X }{ m+ \mu}\}\\
=& - \mathbb{E} \{\frac{\partial}{\partial m}(\Psi(X+ m) - \Psi( m)) +
+ \frac{1}{ m}-\frac{1}{ m+\mu}-\frac{\mu - X}{( m+\mu)^2}\}\\
=& -\mathbb{E}\frac{\partial}{\partial m}\left(\Psi(X+ m) - \Psi( m)\right) -\frac{\mu}{ m( m+\mu)}  \\
=& -\mathbb{E}\left(\Psi(1,X+ m) - \Psi(1, m)\right) -\frac{\mu}{ m( m+\mu)} 
\end{align*}
where $\Psi(\cdot)$ is the digamma function (first derivative of log of gamma function).
Below some maple code (and output):
f :=  binomial(k+m-1,k)*(m/(m+mu))^m * (mu/(m+mu))^k
                                            m         k
                                    /  m   \  /  mu  \ 
        f := binomial(k + m - 1, k) |------|  |------| 
                                    \m + mu/  \m + mu/ 
lf := ln( binomial(k+m-1,k) ) + m*ln( m/(m+mu) ) + k* ln( mu/(m+mu) ) assuming m>0,mu>0;
                                        /  m   \       /  mu  \
 lf := ln(binomial(k + m - 1, k)) + m ln|------| + k ln|------|
                                        \m + mu/       \m + mu/

simplify( -sum(f*diff(lf,mu,mu),k=0..infinity ) ) assuming m>0,mu>0;
                               m     
                          -----------
                          (m + mu) mu

simplify( -sum(f*diff(lf,mu,m),k=0..infinity ) ) assuming m>0,mu>0;
                               0

simplify( -sum(f*diff(lf,m,m),k=0..infinity ) ) assuming m>0,mu>0;
 infinity                                                         
  -----                                                           
   \                                                              
    )     (m - 1)         (-m - 2 - k)   k                        
-  /     m        (m + mu)             mu  binomial(k + m - 1, k) 
  -----                                                           
  k = 0                                                           

  /          2                           2                     2\
  \m (m + mu)  Psi(1, k + m) - m (m + mu)  Psi(1, m) + m k + mu /

