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Questions tagged [crossover]

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3
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0answers
33 views

Pre-post treatment comparison crossover study 2 treatments 2 baselines

I would like to analyse data with a crossover design. Each subject was assigned to a sequence (AB or BA), i.e. 2 periods. Each period consisted of one measurement before treatment (baseline or pre-...
1
vote
1answer
70 views

Mathematical notation / formula of a mixed effect model

I am unsure how to define the mathematical notation of a mixed model of R. I built the model in this way: ...
0
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1answer
117 views

Crossover and mutation with constraints

I had some experience with genetic algorithms during my computer science studies. I wanted to refresh my knowledge and decided to write a simple prototype for automated seating people at tables (e.g. ...
0
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2answers
69 views

Does a p-value of 1 for an interaction where the plot has crossing lines signal something is wrong in a 3-way ANOVA?

I have run a 3-way ANOVA and the interaction between two of the factors looks significant when plotted (i.e. the two lines cross). However the p-value is 1. Should I be worried about this? In ...
0
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0answers
17 views

Crossover healthy volunteer study-multivariate testing

carried out a cross-over study investigating drug/placebo infusion effect on several human pressure paameters in 16 healthy volunteers. A randomised scheme and adequate washout period were used. So......
3
votes
1answer
156 views

Analysis of a cluster crossover design

I am analyzing data from a cluster randomized cross over trial. There are 9 clusters and 3 periods in the data. The clusters are dental clinics and in each period different patients are sampled. I ...
1
vote
0answers
19 views

analytical methods for crossover study that has an addition control group

I have a crossover study where patients perform a cognitive task (with two conditions) when their brain stimulation is switched on and then off. Using a mixed effects regression, I would ensure that ...
0
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0answers
14 views

How to analyze this unusal longitudinal design

I have data coming from an unusual design. 10 subjects were drawn to receive an experimental eye drop for reducing intraoccular pressure. One eye was chosen by random and the drops were applied. The ...
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0answers
23 views

Study the effect of 2 drugs on a symptom caused by 2 diseases

A symptom (for e.g. Headache) can be caused by 2 different diseases (X and Y). Drug “A” acts on both diseases (X and Y). Drug B acts on only second (Y) disease. Disease “X” patients will be treated ...
1
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1answer
27 views

How to study the effect of 2 drugs (used singly and in combination) compared to a placebo on a disease

I want to study the effect of 2 drugs (used singly and in combination) compared to a placebo on a disease. What is the best statistical method? Kindly provide full details.