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2x2 Crossover Trial - minimum observations to run a linear mixed model
I am planning a 2x2 randomized crossover trial with about 20-25 subjects. There will be one measurement (continuous outcome) with period A (intervention) and period B (placebo) for each individual. ...
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Sample size calculation for crossover design using dependent t-test - role of $\rho$?
I am trying to do a sample size calculation for a 2x2 crossover study. I have access to previous studies whereby I can get covariate adjusted estimates of the variability of the responses (from a ...