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Study the effect of 2 drugs on a symptom caused by 2 diseases

A symptom (for e.g. Headache) can be caused by 2 different diseases (X and Y). Drug “A” acts on both diseases (X and Y). Drug B acts on only second (Y) disease. Disease “X” patients will be treated ...
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How to study the effect of 2 drugs (used singly and in combination) compared to a placebo on a disease

I want to study the effect of 2 drugs (used singly and in combination) compared to a placebo on a disease. What is the best statistical method? Kindly provide full details.
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