# Questions tagged [heterogeneity]

Use this tag for questions in the context of meta-analysis; use [heteroscedasticity] in the context of regression modeling. Heterogeneity arises when the primary studies are not drawn from a single population.

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### Calculating Effect Size from Wilcoxon W value (how to get the z value)

Im carrying out a meta-analysis where I have had to carry out my own wilcoxon test on the data. I am now calculating the independant effect sizes for each study to manually input to my excel ...
0answers
11 views

### Finite mixture model, nonlinear, parametric, individuals

Suppose that I think individual $i$ chooses number $c$ according to the formula $c = v(f(\delta, \gamma) x - \alpha y))$ where $v$ and $f$ are nonlinear functions. I know what form $v$ and $f$ take. I ...
0answers
22 views

### Hartung-Knapp-Sidik-Jonkman variance correction in meta-analysis

I am doing a meta-analysis of continuous data (SMD), number of studies (k) around 75, heterogeneity high (Tau-squared around 0.15, I-sqr over 75%). Our interest is in fact in a key subgroup analysis (...
0answers
28 views

### Equivalence between interaction and second difference measures of heterogeneity

I am trying to understand a paper used by Frank Harrell in his biostats course to demonstrate how NOT to present results from an analysis of heterogeneity of treatment effects (HTE). Frank's point is ...
2answers
209 views

### Meta-analysis: How to interpret a non-significant Q statistic but high I squared

I'm reviewing some meta-analyses on psychotherapies and trying to make sense of the statistics related to heterogeneity, specifically Cochran's Q and the I-squared value. I'm confused about how to ...
2answers
48 views

### How can I account for heterogeneity at the author level in a meta-analysis?

Suppose that my meta-analysis has several studies performed by the same author. There could be heterogeneity at the author level (because perhaps the author is not very attentive, or uses different ...
0answers
27 views

### LOOKING FOR THE OPTIMAL MODEL WITH GAMM

I conducted an experiment where earthworms were subjected to two treatments, with and without herbicide in the soil. Biomass measurements were taken every 12 days for 398 days and the biomass growth ...
0answers
180 views

### correlation with diverse characteristics

What does it mean to say "incidental parameter bias due to correlation between past realizations of the data and the unobserved heterogeneity (diverse characteristics)"? How can there be a correlation ...
0answers
110 views

### Difference in Difference heterogeneous treatment effect based on scale of pre-post difference

In a Triple Difference model can we introduce a dummy variable based on scale of difference of dependent variable between pre and post periods? Example: divide both treatment and control groups into 2 ...
0answers
78 views

### One-way ANOVA method validation

Here is my case: Let's say we have 50 polygons(looks like this:and a point set distributed within these 50 polygons. So that for each polygon, there is an associated point density. What I want to test ...
0answers
19 views

### Moderator variable in meta-regression analysis and treatment effect heterogeneity

Meta-regression may reveal that variable A explains heterogeneity in pooled treatment effect of X. In a clinical trial I can investigate whether there is interaction between treatment allocation and ...
0answers
41 views

### Applying Heterogeneous treatment effects to clinical research (non technical explanation)

I'm trying to understand the hype around this estimation of heterogeneous treatment effects in the machine learning literature lately. It seems super interesting, but alot of it is beyond me. I read ...
0answers
102 views

### Using multinomial logistic regression to test for heterogeneity

I have been asked to use polychotomous logistic regression to test for heterogeneity or independent variable across multiple outcomes levels, and then change-in-estimate method to identify other ...
0answers
97 views

### Looking for R package or function to quantify heterogeneity/homogeneity of groups of character strings [closed]

I’m looking for an R package or function that I can use to measure the relative homogeneity/heterogeneity of groups of character strings. There are about 50 groups, each with thousands of character ...
0answers
184 views

### Calculation of I-squared in meta-analysis of diagnostic accuracy

I would like to calculate heterogeneity statistics (Cochran's Q, I-squared) for a meta-analysis of diagnostic accuracy. I successfully used the 'mada' package in R to calculate these statistics, but ...
1answer
344 views

### Conducting a subgroup analysis with regression modeling

I'm conducting a survival analysis using Cox Proportional Hazards regression to identify prognostic factors for cancer patients. My covariates include information such as age, sex, tumor location etc. ...
0answers
94 views

### Why is Metafor R package giving an I2 for fixed effects meta-analysis model (rma.uni)? [closed]

I'm trying to run a fixed effects meta-analysis using the Metafor R package and in the documentation I read that it does not return an I^2 for fixed effects models, only for random effects models. ...
2answers
373 views

### Are there good alternatives to Cochran's Q test for heterogeneity in meta-analysis?

We used the Q test to determine heterogeneity with p-values <0.10. A highly recognised statistician commented that the Q test has low power and that it should not be used to determine presence of ...
1answer
73 views

### Re: Random Effect Model in Binomial Proportions Meta-analysis

I have used a random effects model for the meta-analysis of binomial proportions and have encountered several queries. In one meta-analysis, I have four studies. Sample size of 98, 58, 107, 62 ...
0answers
52 views

### Homogeneity test in survival meta-analysis with adjusted HR

I was wondering what was the way to measure heterogeneity in a survival meta-analysis. I have for each study, an hazard ratio calculated with a penalized cox model (...
1answer
103 views

### Heterogeneity test in meta-analysis

In a random effect meta-analysis model with one categorical independent variable $\theta_{ij}=\theta_i+s_j+\epsilon_j$, where $\theta_{ij}$ is the observed effect size in category $i$ in study $j$, \$\...
3answers
198 views

### Is it worth doing (single-armed) meta analysis if the studies' heterogeneity is very large?

I'm currently trying to perform a single-armed meta analysis of immunotherapy on breast cancer, which I believe this meta analysis will be the first among its intervention and cancer subtype. The ...
0answers
27 views

### What heterogeneity test is appropriate for my study? And, what is the use of correlation between median PFS and median OS [duplicate]

I want to perform a meta analysis of a particular subjects of cancer. My effect sizes are Overall Response Rate (ORR), Disease Control Rate (DCR), Duration of Response (DOR), Progression-Free Survival ...