Questions tagged [medicine]

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23 views

Why we use precision/recall in binary classification but sensitivity(=recall)/specificity in medicine?

Sensitivity=recall is used in both fields, but the second metric is different. Why? Both tasks (classification and medicine) look same - data has two classes and we do some predictions on it and want ...
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7 views

Number of preventable events

How would you calculate the following problem? I want to calculate the number of potential preventable events with increasing medication use in a population. For example, say there are 1000 people in ...
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18 views

Drop or impute predictor that is missing around 70% of values, but which is known to be highly relevant?

Suppose we have a medical dataset and we are interested in predicting blood pressure using the following variables: age, sex, weight, height, volume of circulating blood, cardiac output, parent with ...
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16 views

Deriving Peto odds ratio?

I read the paper using Peto odds ratio method for a research. (Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction: An overview of the randomized ...
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1answer
19 views

Which test fits the best here? (oncogenic signalling pathways)

I have a list of patients in rows and oncogenic signalling pathways in columns of two independent matrices One for responders to a drug one for non-responders to the same drugs If a patient gets ...
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15 views

pre and post test at multiple time points under two treatment conditions

I am designing a research study to study the effects of exercise on the immune system in people with a specific illness. I would like to draw blood before and after and exercise intervention at three ...
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16 views

How to interpret this prepost ANCOVA test result?

I have a basic pre-post trial design. Two randomized Groups and two tests for each participant in each group one prior to the intervention (here V1) and one post (V2). I am completely new to this and ...
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13 views

How can I use Karman Filter or any other filter to better estimate Blood Glucose values and give the right amount of Insulin?

Right now, I just have Blood Glucose/ Time values and also the graph which contains those values. But, the obtained Blood Glucose values hardly remain in the desired range. So, I was wondering if ...
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15 views

Where to find pre-trained models for transfer learning - for tabular data to solve the classification of cardiovascular disease or related

Most transfer learning models suggested are for image classification, where can I find models to use as a weight initialization scheme to predict Cardiovascular disease? The data is tabular, ...
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3answers
96 views

Regression in Causal Inference

I was recently introduced to the topic of causal inference in statistics and I am currently learning about the importance of the backdoor criterion (BDC), as applied to the following DAG. Interest ...
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32 views

Is there a way to deal with spiking growth rates due to small sample numbers?

I'm looking at plotting county coronavirus case density growth rates (moving 7 day window) and am finding that when cases first appear the new case growth rate is very large due to the fact that there ...
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2answers
99 views

Understanding Medical Testing

While reading a textbook on probability I came across a question: There is a probability that a certain percentage of the population has a disease. Then a test for this disease could have a certain ...
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1answer
32 views

Comparing data with two timepoints in two groups with categorical classification

I'm hoping you can help me find an analysis best suited for my purpose. I have a dataset structured like this: Basically, subjects are measured twice and get a score. If the score remains roughly the ...
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1answer
16 views

multilevel factor odds ratio - help SPSS

I'm a newbie when it comes to SPSS and Statistics, and in need of some help. I would like to know how to calculate a multi level factor odds ratio in SPSS, for an outcome (0 vs 1 : no disease vs ...
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1answer
43 views

How to model logistic regression with a predictor that predicts another predictor in the model

I'm trying to answer a question about whether resident (surgical trainee) presence increases the risk of complications during surgery, and I'm trying to figure out how to include total operative time ...
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2answers
34 views

How to do meta-analysis of diagnostic tests with only sensitivity and specificity?

I am a junior physician, and I've run into some problems with the meta-analysis of diagnostic tests and I was hoping to get some input. Some background: Aside from my undergraduate statistics courses ...
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1answer
19 views

Patient's data anonymisation

Is there any available statistical method for assessing whether anonymisation performed on patient data in a medical dataset is sufficient?
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2answers
73 views

How to interpret regression coefficient when adjusting for baseline

I want to estimate the effects of sex on sodium level at follow-up after starting treatment with a thiazide (diuretic medication). The cohort consists of persons starting thiazide treatment. Follow ...
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19 views

Heart rate vs sleep quality ( need advise about statistical strategy for better compare)

I LIKE TO KNOW ABOUT how to compare result of some detected patters in heart rate for sleep quality,for something like this work: Image-based sleep motion and Slope detection on Hammock, hill and ...
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17 views

Want to determine the safest site for a femoral arterial puncture

We collected the data form CT scans of 200 cases as follow: The site of the bifurcation in relation to head of femur in each patient from (1-5) and according to the pubic tubercle (1-3). The site of ...
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6 views

Reporting significance values for relative risk (RR) and number needed to treat (NNT)

I have calculated the relative risk & number needed to treat using the log-binomial regression model. NNT is calculated as the reciprocal of the marginal difference. Does it make sense to report ...
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9 views

Create synthetic data based on general description of molecular characteristic for modeling

I have a modeling task that classifies cancer subtype based on several molecular features. However, I do not have raw data of tumor sample to extract these features. All I have are several published ...
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1answer
63 views

How to determine the best non-linear regression model? Metabolomic analysis of different tumor sites

I have performed some metabolomic analysis of different tumor sites and would like to see if there are any correlations between the metabolite levels and some of the tumor characteristics that I am ...
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50 views

Is Group Testing feasible (for a virus) when individual testing is not viable (as was done for disease screening of draftees in WW II)?

Background: Today, Andrew M. Governor of the State Of New York, stated (and he claims for the very first time the use of the word ‘cannot’ in his news briefing), that he could not possibly test on ...
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2answers
46 views

Probability of disease in a patient with risk factor

I'm a doctor so I'm sorry for my basic knowledge of statisctics. I have a prior probability of the disease D $$P(D) = 0.12$$ I know that risk factor RF can cause the disease. Total probability of ...
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12 views

Finding Model/Technique to find effect of alcohol prohibtion on health outcomes

As a study project, using Stata, I'm trying to figure out the effect alcohol prohibition in Kerala state had on health outcomes of Keralans. I did some preliminary descriptive statistics with Stata ...
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13 views

How to correlate multiple time series data for medical data?

I am working on a university project and the next step is to find the correlation between 1) and 2): ...
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14 views

Procedure to Smooth Noise for Threshold Values

Suppose I am looking at an estimate $\hat\beta$ in a clinical trial data. With $a=.05$, a patient with $\hat\beta>1$ is considered to have some medical condition. A daily example could be a 24-hr ...
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27 views

Which test I should use

I have a big clinical data file with 96 columns like age, gender, BMI, etc I want to see which of these clinical characteristics relate to response to chemotherapy....
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1answer
41 views

What's the appropriate test to be used in this study?

I was asked by an acquaintance of mine for support in interpreting a medical study. I don't work in healthcare, thus of course this was not professional advice. Two groups of people of size $n_1$ and ...
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27 views

Research question: We measured heart rate variability parameters

In my research we measured heart rate variability parameters (4 different numerical variables) in 4 different situations in 50 subjects - newborns who were of different age. How to control the sample ...
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27 views

I want to analyze the relationship between diabetes mellitus and hypertension?

I have data of blood pressure, fasting blood glucose and post prandium ( which means blood glucose level after 2hrs of having lunch). I wonder if I have to analyze with each data such as fasting ...
2
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1answer
39 views

statistical comparison of overtime response to contrast media injection

I'm a medical doctor with no statistical skills, and I need some help on what kind of test to run. I have a set of 20 patients who underwent CT brain perfusion multiple times (twice in most cases, ...
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32 views

What statistical model is this study using?

I am new to statistics and I need to know how to describe the statistical model of this study in my abstract. A retrospective medical study assessing the risk factors predisposing someone to a an ...
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34 views

Is the shrinkage of subgroup analyses in meta-analysis an example of Stein's paradox?

This paper writes (edited for concision): Consider, a doctor in Germany confronted by a meta-analysis of long term‚ $\beta$ blockade after myocardial infarction. Although a robust beneficial effect ...
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1answer
29 views

Would “correcting” for patient characteristic in a cohort study always strengthen the study?

If we are doing a cohort study and investigating whether a variable has an effect on an outcome (say tumor size on nausea), and we run a regression (or chi2) with nausea as a dependent variable and ...
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1answer
23 views

Unsupervised Odd-one-out - paper recommendation

Abstract Problem: I have several series (sharing the same class) of about 400 small images each. Each one of my series has >390 images, that belong together. The rest of the images shares the style of ...
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1answer
32 views

Admissions per year before and after antibiotics?

I need to compare hospital admissions per year before and after the introduction of antibiotics in 100 patients (antibiotics introduced at various time points in the past). Eg. Before antibiotics: ...
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48 views

Bland-Altman analysis in critical scenario?

I am analyzing some medical data about distance of tumor lesions from surgical resection margins, measured with two different protocols (say, protocols A and B). The overall idea would be to compare ...
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16 views

Looking for statistics suggestion for data set: EEG “Diagnostic” measurement comparison - non-parametric/ordinal - large proportion of zeroes

I was hoping to get some input on handling a particular data set that falls outside of the purvue of the a lab I am apart of (usually outcomes research). The data consists of a pair of repeated ...
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180 views

“Unselected sample” vs “random sample”

I've just encountered the term "unselected sample" for the first time, which seems to be fairly commonly used in medicine. Example usages: Climacteric symptoms in an unselected sample of Swedish ...
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1answer
23 views

number of samples needed to show difference between two samples

I am an opthalmologist not trusting what the drug companies are telling me so need some help I am looking a papers on glaucoma where the pressure of the eye is measured. The SD of the measurements is ...
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1answer
76 views

Visualization associations between the symptoms - categorical data in R

I have a data frame with presence of symptoms which are categorical data (1 = present, 0 = absent). For instance: ...
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82 views

book recommendation - statistics in medicine

Could you recommend a book about the implementation of basic statistic concepts in medicine? In particular, I want to find a book that covers principal component analysis, correspondence analysis and ...
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14 views

Significance test for Patient Years

Previously, I had a question about CI for Patient-Years (py) and there was a great answer from @TamasFerenci. Now I need to find out the $p$ value for the py of two different groups. I have a table ...
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2answers
443 views

How to get confidence intervals for Patient-Years?

In medicine patient-years is a popular concept. Example: $100$ patients are followed for $2$ years. In this case, there are $200$ patient-years in total. If there were $8$ myocardial infarctions in ...
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16 views

How to analyze time series data with very few samples for response variable

I want to use R to model a person's blood-iron level to predict how it changes over time. My response variable is blood-iron level and my explanatory variables are related to diet, use of different ...
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2answers
81 views

Medical efficacy confusion

On this page one can find the following statement: Magnitude of Effect: Vaccination against HPV-16 and HPV-18 reduces incident and persistent infections with efficacy of 91.6% (95% confidence ...
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45 views

Particle filter for diagnosis

I have two annual measurements taken on medical images depicting a lung cancer tumor 's condition. I have likelihood function that taken in the measurement values and estimates malignancy of the tumor....
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35 views

How do I divide a density/frequency plot?

I have a frequency plot, which is essentially a smooth histogram. There are three very clear features (divided with a line by eye). Please note, there are two groups, male and female. The data used to ...