Questions tagged [meta-analysis]

Methods focused on contrasting and combining results from different studies, in the hope of increasing precision and external validity.

Filter by
Sorted by
Tagged with
0 votes
0 answers
4 views

interpretation of moderation in meta analysis

I'm conducting a meta-analysis using package metafor in r and I want to test the possible moderation effect of 3 variables. Of the 3 variables, only one gives me a significant effect on the '...
user avatar
1 vote
0 answers
23 views

Combining continuous outcomes in a meta-analysis using same individuals (doses, time periods/repeated measures, and behaviors)

I’d like to get some advice regarding a meta-analysis study, and including multiple groups from one study. I’ll preface this by stating I’m very new to meta-analyses and that this is a solo ...
user avatar
2 votes
0 answers
25 views

is meta-analysis of combined raw/fully disaggregated data appropriate?

I have conducted several experiments that examine Reaction Time as the DV. Because I conducted them, I have the raw data for each. It makes sense to me that combining all the data (at the single-trial ...
user avatar
1 vote
1 answer
22 views

Outlier study in a meta-analysis

Im currently working on a meta-analysis of randomized controlled trials (RCTs). These RCTs have reported their outcomes at different time points. The maximum follow-up points were as follows: 1 months,...
user avatar
1 vote
0 answers
11 views

Meta-analysis of binary outcome data where both arms have 100% events

I am running a meta analysis of events between two different groups. In one paper the event rate is 100% in both groups and no box is generated. I'm aware that Cochrane recommends excluding papers ...
user avatar
  • 11
2 votes
1 answer
46 views

Multi-centre survival analysis

I have question regarding survival analysis. I am looking at observational studies comparing patient survival who received treatments A or B at different centres (>10), for the same condition and ...
user avatar
  • 37
2 votes
0 answers
22 views

How can I compare Pearson's Correlations from a "Mini Meta"?

I'm trying to conduct a "mini" meta-analysis on a series of 6 studies I've conducted. With regards to the mini meta itself, I've used the steps outlined in this article (and the associated ...
user avatar
0 votes
0 answers
20 views

Can there be negative values for doses in one-stage dose-response meta-analysis?

I am trying to perform a one-stage dose-response meta-analysis as described by Crippa et al. https://pubmed.ncbi.nlm.nih.gov/29742975/ However, I am assessing the change in alcohol intake over time as ...
user avatar
2 votes
1 answer
40 views

Subgroup of one study in a meta-analysis

Im currently working on a meta-analysis of randomized controlled trials (RCTs). These RCTs have reported their outcomes at different time points. I decided to split the data of these studies into sub-...
user avatar
1 vote
0 answers
21 views

meta-analysis with point-biserial correlation using metafor

I would like to conduct a meta-analysis on the association of a continuous and a dichotomous variable. In order to compare the result with previous meta-analysis I woud like to use the point-biserial ...
user avatar
  • 11
1 vote
1 answer
28 views

In a survival meta-analysis shouldn't you use HR instead of RR?

I found this interesting survival meta-analysis: https://pubmed.ncbi.nlm.nih.gov/23216926/ Why do they compare OS between the different studies using RR and not HR? Indeed the authors of this paper ...
user avatar
  • 21
1 vote
0 answers
27 views

Can you use both fixed-effects and random-effects models in the same meta-analysis? Shouldn't you use just one model?

This is just an example, but I've found many of them: https://pubmed.ncbi.nlm.nih.gov/23216926/ Thank you very much in advance!
user avatar
  • 21
1 vote
0 answers
39 views

Egger's test, Trim and fill method and funnel plots for three-level meta-analysis

I have performed a three-level meta-analysis in R (based on correlations) to estimate an overall association and to perform moderator analyses following guidelines of Assink & Wibbelink (2016). ...
user avatar
2 votes
0 answers
14 views

Arm-based meta-analysis of variation and mean with interval scale data

I’ve been extracting data for an arm-based meta-analysis on the distribution of a self-report survey in various research contexts. I am interested in the approach taken in Nagakawa et al. (2015), ...
user avatar
0 votes
0 answers
37 views

How to calculate the proportion of heterogeneity accounted for by moderators in a multi-level random-effects meta-analysis?

I have conducted a multi-level random-effects meta-analysis using the "metafor" package in R and have been asked by a reviewer to report the proportion of heterogeneity accounted for by ...
user avatar
  • 85
1 vote
1 answer
17 views

Incorporating Posterior Samples In Bayesian Meta-Analysis

I have results from 25 experiments that include an estimate of mean effect and a thousand posterior samples of the effect. Rather than use the standard deviation of these posterior samples as the ...
user avatar
1 vote
0 answers
23 views

Meta-analysis of paired count data

I have data from 70 studies reporting number of observed events in two time periods, one before Covid and one during the Covid pandemic. The duration of the timeperiods and the size of the population ...
user avatar
  • 171
1 vote
1 answer
99 views

Including multiple treatment and multiple endpoint studies in meta-analysis using metafor

I am running a random-effects multivariate meta-analysis with the package metafor. I have binary data with one treatment and one control group. I am interested in the overall effect of the treatment. ...
user avatar
  • 11
2 votes
0 answers
54 views

Meta-analysis in R: multiple effect sizes with unknown correlation

I'm working on a meta-analysis with multiple effect sizes reported in most studies. My effect sizes are SMD between two groups (health/ disease) and the reason there is multiple effect sizes per study ...
user avatar
  • 21
1 vote
1 answer
44 views

Three-level Meta-Analyses: correlation comparisons and correction for publication bias?

I'm conducting a three-level meta-analysis on correlations using the {metafor} package on R. I'm quite a newbie when it comes to three-level meta-analyses, so I have two doubts. 1) From each study, I ...
user avatar
  • 13
1 vote
0 answers
17 views

Meta-regression for continuous data - effect size or otherwise?

I'm trying to parse the output of multiple studies to quantify how age impacts the prevalence of HPV in Europe. Thanks to an excellent suggestion in a previous question, it has been suggested that ...
user avatar
  • 229
2 votes
0 answers
16 views

Suggest ways to represent additive fixed effects?

The dataset I'm working with has additive fixed effect where each term is significant. I want to plot the model fit with one of the factors temp here on the x-axis ...
user avatar
2 votes
1 answer
36 views

Calculating sampling variance in multilevel meta-analysis

I'd like to conduct a three-level meta-analysis using R. I see that several papers recommend calculating the level 1 sampling variance using Cheung's 2014 formula 14. However, I'm wondering if it is ...
user avatar
  • 23
1 vote
0 answers
12 views

Synthesis without meta-analysis, z-score for 2 proportions?

I am doing a meta-analysis. One of the outcomes I meta-analyzed involved pooling multiple types of related complications. There wasn't enough data to pool the individual reasons for the complications, ...
user avatar
2 votes
1 answer
23 views

Interquartile ranges of 2 groups in meta analysis

I am performing a meta analysis of mutliple trials (Intervention vs. Placebo) and wanted to describe the baseline characteristics in a table. Some trials report continous variables as medians and ...
user avatar
  • 37
1 vote
0 answers
20 views

Meta-analysis of "adjusted r-squared" from multiple prediction models

Using data from multiple cohorts, I am trying to check the performance of a prediction model I developed. The plan is to get the Adjusted r-squared from 2 models, one model has the score and the other ...
user avatar
0 votes
0 answers
17 views

Meta-analysis with ratio data

I am currently performing a meta-analysis where the outcome of interest is the ratio between the concentration of two sugars in urine/plasma (i.e. the results of dual-sugar test; see: https://doi.org/...
user avatar
1 vote
1 answer
55 views

Meta - analysis for paired data (individual patient data, IPD)

I've got data for three experiments, pre-post data, where I have all the individual level data (not shown). I want to produce a comparison with summary data in the form of a meta-analysis and forest ...
user avatar
  • 11
6 votes
1 answer
139 views

Expected Fisher information isn't positive definite for truncated normal with heteroskedasticity

This question is about having a non-positive-definite expected Fisher information in a normal model in which observations have different dispersions. Consider this simple normal model: $$Y_i \sim N(\...
user avatar
  • 3,501
1 vote
0 answers
41 views

Is it reasonable to report $I^2=0$ with confidence interval [0, 100] in a meta analysis?

Is it reasonable to report $I^2$=0 with 95% confidence interval [0, 100] in a meta analysis manuscript? I was not sure since the CI covers all possible values. $I^2$ is a commonly used heterogeneity ...
user avatar
  • 205
1 vote
0 answers
18 views

Problem fitting quadratic model in 'dosresmeta' package due to error regarding "leading minor"

I am trying to use the doresmeta package in R to evaluate the dose-response relationship between supplemental intake of a micronutrient and risk of a disease. When ...
user avatar
1 vote
0 answers
25 views

Meta analysis average percentage difference with standard error

I am collecting data on the effect calorie labeling has. Each study provides a value for mean calories consumed before the calorie label and after. Each number has a standard error or deviation ...
user avatar
  • 11
1 vote
0 answers
22 views

InfluenceAnalysis of Meta-Analysis

I am coming here hoping for help, which I could not find anywhere else. I am a physician doing research on prognosis of patients with certain autoimmune disease. Currently, there is variety of ...
user avatar
0 votes
0 answers
24 views

Metaanalysis and influence analysis

I am currently performing a meta-analysis of hazard ratios (HR) in the R studio. Given high degree of the between-study heterogeneity (I² was around 65%), I have decided to perform influence analysis ...
user avatar
1 vote
0 answers
36 views

How to compare ANOVA results from multiple data sets

I am trying to find out if there is an age-education category difference between people in the number of votes which they use while voting with a multiple vote voting method. Basically, I am trying to ...
user avatar
1 vote
0 answers
41 views

How to meta-analyze incremental validity

Suppose we have two instruments (A and B) and we want to meta-analyze whether instrument B has incremental validity over instrument A in predicting an outcome Y. What effect size would be most ...
user avatar
1 vote
1 answer
52 views

Selection Models of Publication Bias for Multilevel Meta-analyses?

Are there any suitable selection models of publication bias for multilevel meta-analyses? I am currently conducting a 3-level meta-analysis and trying to incorporate selection models to assess ...
user avatar
  • 53
1 vote
1 answer
41 views

Can you statistically compare two indirect effects in metaSEM?

I'm conducting a meta-analytic structural equation model (MASEM) using the two-stage approach in metaSEM in R. I have fit a model with two indirect effects, and ...
user avatar
2 votes
1 answer
85 views

Meta Analysis in R (metafor): How to interpret a multi-level mixed effects model with intercept and without intercept?

Dears, I am having trouble making sense of two MLMEs I did using rma.mv(). I am using a factor variable with 4 levels as a moderator. The two outputs (once with ...
user avatar
  • 33
1 vote
0 answers
24 views

Meta Analysis (metafor in R): Difference between Mixed-Effects Models that have an intercept and those who don't? [duplicate]

My question is more theoretical, less code related. I am trying to enter some moderators to rma.mv() , my moderators are: 1 factor with 4 levels. Call it "F&...
user avatar
  • 33
1 vote
0 answers
18 views

Way to simulate or calculate event numbers in survival analysis?

I would like to conduct a meta analysis on a subgroup that's often included in larger studies but not typically studied alone. I am trying to investigate the effect the presence or absence of a ...
user avatar
  • 11
2 votes
0 answers
39 views

Meta-analysing impact of Covid pandemic on risk for perforated appendicitis

I am analyzing the impact of the change in the management of appendicitis during the covid pandemic. I have paired data from 31 reports comparing the number of operations for perforated and ...
user avatar
  • 171
3 votes
0 answers
49 views

Why are GLMMs distinct from GLMs for Meta-analysis of study level data?

Would anyone be able to explain conceptually why GLMMs with a random intercept at the study level are occasionally used for meta-analysis of proportions / counts, when the observations are already at ...
user avatar
2 votes
2 answers
56 views

Testing for differential ranking between lists relative to a reference list

I am interested in comparing ranked lists in order to find elements that are differently ranked. Suppose we have 10 lists, each ranked (and for simplicity assuming the elements overlap and only the ...
user avatar
  • 91
2 votes
1 answer
37 views

Completely different inferences between single-trial difference and meta-analysis comparison

I have the following data ...
user avatar
  • 471
4 votes
1 answer
204 views

Egger's regression test for funnel-plot asymmetry in a meta-analysis using metafor

My meta-analysis investigates the association between dietary intake of a micronutrient on the risk of being diagnosed with a disease (binary outcome). I am trying to test for funnel-plot asymmetry of ...
user avatar
1 vote
0 answers
34 views

Meta analysis in R with changes from baseline scores: SMD interpretation and sample size selection

I have two questions regarding a meta-analysis I am currently running. 1. SMD interpretation for change from baseline scores In this meta-analysis, I have change from baseline scores and I am ...
user avatar
1 vote
0 answers
9 views

How to describe the type of analysis which use large Electronic Health Records? meta analysis? big data analysis?

I have got access to large amount of EHR (electronic health records) of one of the largest health insurance in my country. I intend to pull out some clinical parameters and analyze them using machine ...
user avatar
1 vote
0 answers
12 views

Rerunning requests in meta-analysis

When performing a meta-analysis, is it advisable to run database requests more than once (i.e. not only in the initial inclusion phase)? If so, what is the expected added value? If not, how to deal ...
user avatar
1 vote
1 answer
29 views

3-level meta-analysis: Level 3 (study level) has a variance of 0, should I drop this level?

I am doing a 3-level meta-analysis. First, I fit a theoretically-driven model, where level 1 is the sampling variance, level 2 is the effect level, level 3 is the study level. This method is well ...
user avatar
  • 53

1
2 3 4 5
26