Questions tagged [meta-analysis]
Methods focused on contrasting and combining results from different studies, in the hope of increasing precision and external validity.
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Sample size calculation in a meta analysis in ecology
I am conducting a meta-analysis in the ecology discipline, such as on the effect of elevated CO2 on soil organic carbon. In my case, treatment and control groups have different sample sizes within the ...
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Aggregated range for multiple confidence intervals
I am conducting a simulation involving 40 different stores in a specific area. Each store receives a varying number of customers in a given time period. I am calculating the expected final margin and ...
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Meta-analysis of single arm study to compare different interventions
I have a collected data regarding single arm studies treating certain disease with either technique A or technique B with no direct comparison between the techniques in each of the studies. for ...
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Score Normalization for Moderator Analysis in Meta-Analysis
I’m conducting a meta-analysis on the association between LGBTQ+ discrimination and mental health. Both are continuous variables, and I am analyzing correlation coefficients. I’m interested in looking ...
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Best approach to assess meta-analysis heterogeneity when a study has sampling variance of zero
I am currently performing analyses for a meta-analysis looking at the mean difference of pre-post intervention data (i.e., 'mean change'). However, one study reports identical mean and SD for the pre- ...
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Can you combine effects from both the composite and domain levels of questionnaires in a meta-analysis?
First time posting here.
I am collaborating on a meta-analysis investigating the association between fatigue (in a specific clinical population) and cognition. I have done a few meta's before so I am ...
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Is it possible to perform a meta-analysis of multiple outcomes and multiple predictors?
I have a pool of 20-ish quantitative studies that report odds ratios for a particular outcome (e.g. homelessness) but most studies will also report a few more outcomes. All of these studies report the ...
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Meta-analysis of within-person designs with multiple treatments
I have a question about how to conduct meta-analyses appropriately for (a) within-person designs where (b) the experiments comprise of multiple treatments.
Assume each experiment consists of three ...
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Creating forest plot and conducting subgroup analysis using robumeta
Thanks again for everyone's comments on my previous post UPDATE Conduct proportion meta-analysis using Robumeta package -forest plot and subgroup analyses and it seems like the proportion meta-...
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UPDATE Conduct proportion meta-analysis using Robumeta package -forest plot and subgroup analyses
UPDATE: Thanks again for everyone's comments on my question and it seems like the meta-analysis is now working finally after creating a separate column on variance.
The robumeta package has now ...
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Can I do a Meta-Analysis for Odds Ratio's for continuous predictor (age) with Binary outcome (Affliction, yes or no) in R?
I'm looking for a way to conduct a Meta-analysis on Odds Ratio's from several studies/article's. The thing is that my OR's are based on logistic regression's with continuous predictors (outcome is ...
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How to get the pooled estimate and I-squared test for heterogeneity either in STATA or R
I am trying to do meta-analysis using a numerical variable (caculated dose value from different studies) with their sample sizes. I am planning to get the summary of the dose variable as follows with ...
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Meta-analysis of log transformed and untransformed Y!
First off, it's difficult to title the question without the knowledge of the field, Please bare with me as I, very much a novice, attempt to explain the issue:
I have summary statistics for over a ...
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Unifying multiple sample data (meta-analysis)
I would like to unify multiple sample data (of different sizes) into some "unified sample" to evaluate its collective variance. Is this something statisticians do? I thought of unifying ...
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Metafor trim and fill procedure after identifying publication bias
I am using the metafor package to assess publication bias for a meta-analysis (included approx 100 and approx 900 individual effect sizes). I am facing an issue with the implementation of the trim and ...
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how to derive standard error for ROC and how to compare 2 ROC area under curve meta-analytic estimates in R using metamisc (Bayesian random effects)
I am trying to do a meta-analysis to pool many ROC curves together and get an estimate of cumulative AUC using 2 different ...
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How to interpret a meta-regression output?
I've conducted meta-regression analyses using the 'metafor' package in R. I am trying to interpret the outputs if you could please help?
Output 1 (categorical with 3 levels): Test of moderator is ...
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Understand mixed model for meta analysis?
I am using a mixed model meta analysis, for combining several studies, more specifically doing a linear model adjusting for covariates within each study, and then pooling the estimated effect size, to ...
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Converting a Least Significant Difference to Standard Errors for a Meta-Analysis dataset
I am attempting to perform a basic meta-analysis using crop yield response rates, and to do that I need both mean outcomes under treatment vs. control and their respective standard errors. While most ...
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Pooled analysis of different but very similar measures; what is the best practice?
I have three small data sets which include scores on global cognitive assessments. Two data sets use the score on the Mini Mental State Exam, one uses the score of the Montreal Cognitive Assessment. ...
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(Bayesian) meta-analysis for circular-linear correlation
I am working on a meta-analysis exploring the relationship between sleep and memory. In one session, I am interested in conducting an analysis on the circular-linear correlation between a circular ...
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Longitudinal, repeated measures, multivariate meta analysis
I am trying to carry out a meta analysis with proportions in which I calculate the % of patients
with response and/or remission (measured with the same scale) to a treatment at determinated time ...
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re: binary random-eff meta-analysis: Why is my heterogeneity estimate so much higher using GLMM compared to other methods? (metabin function)
I am trying to conduct a random effects meta-analysis for binary outcome data using the GLMM method in the meta package (metabin function / meta package).
meta package citation:
Balduzzi S, Rücker G, ...
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Dependent moderators in meta-analysis
I am running a three-level meta analysis with about 250 included studies and ~1200 contrasts. I try to get a glimpse on the heterogeneity by running moderation analyses. However, I know that most of ...
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Interpretation of prediction intervals in a random-effects meta-analysis when tau^2 is 0
I'm reading a meta-analysis that compared the risk of an adverse outcome in the intervention and control group. The meta-analysis yielded a summary effect size (risk difference) of +3.9%, with a 95% ...
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Are there guidelines on systematic reviews of meta-analyses?
Systematic reviews are typically performed on single papers. Nevertheless, the concept of "systematic review of meta-analyses" is not new (see, for example, here:pdf). Are there guidelines ...
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What's the best model GEE or lmer?
I have access to individual data from 3 different studies. The first one has measurements of the variable of interest at baseline and 5 days after the intervention. the second one has measurements at ...
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Comparing Diagnostic Attributes in a Meta-Analysis of Diagnostic Performance
I'm currently conducting a meta-analysis in which I compare the diagnostic performance of two different methods. All the studies in the analysis employ the same reference standard. The pooled ...
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It is possible to calculate the Hazard Ratio and 95% CI on different reference groups
I'm working on a meta-analysis and pooling hazard ratio (HR) using the metafor package in R. While most of the studies compare two categories (Biopsy vs Surgical resection) some studies report HR and ...
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Calculating SD for Change in time
I'm conducting a meta-analysis on weight change (T2 - T0) between Group 1 and Group 2. The data I have typically looks like this:
Weight (kg)
Group 1 (n=15) | Group 2 (n=14)
T0 65.31±16.49 | 59.06±...
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How to compare and summarize continues and factorial designed experiments?
I am new here so I hope this question is expressed properely. I would like to compare a summary of factorial ordinal experiments with e.g., 4 concentrations to studies using a continues vector IV. To ...
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How to transform GEE coefficients to Cohen's d (standardized mean difference) for meta-analysis
I am conducting a meta analysis and am looking into how to convert coefficients (with SEs) from a GEE linear estimation into a standardized mean difference, Cohen's d. Does anyone have any hints on ...
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How can one get a non-zero failsafe-N for non-significant meta-analysis?
I have been working with the attached data. Using the (wonderful) metafor package I fit a random-effects model, which generates the following outcomes:
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Calculation of standard deviation of the mean changes from the p-value or z-value of the Wilcoxon test
I am conducting a meta-analysis of observational studies without a control group that compared a parameter's value before and after an operation. All included studies have reported their results as ...
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Comparing my survey results to results from the literature
I’m running an initial study to decide whether a RCT is worth the time and resources. I have survey results from a treatment group, but unfortunately no control. Is there a reasonable way for me to ...
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Meta analysis: can multiple test corrections (i.e. Bonferroni) be applied on the pooled effect p-value?
I plan to do a meta-analysis including the effect size of each cohort as the objectives. I'd like to ask if I could apply multiple test corrections (i.e. Bonferroni) on the pooled effect p-value.
I ...
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Combining RR/OR
I am doing meta analysis for my thesis and I have a problem with my data. I want to investigate whether psychiatric comorbidity have effect on increasing risk to my outcome. I got 3 studies that ...
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Why do tau2 and I2 estimations differ between frequentists and Bayesian models
I was conducting a network metanalysis of treatments and found out that I2 and tau2 esitmates are widely different between the models (as an example, for the same outcome, I have a tau2= 0.0078 and I2=...
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Including study as a moderator in a meta-analytical model
I'm trying to figure out what it means to include 'study' as a moderator in a meta-analytical model. In the R package metafor, for example, we might build an intercept-only random effects model as ...
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Meta-Regression with BDI mean difference as a predictor?
I am conducting a Meta-Analysis using metafor in R.
I calculate the standardized mean difference between patient groups (PG) and ...
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Pairwise correlation based on effect size values with missing values of some variables
I have data with seven variables and I want to calculate pairwise correlation (also the significance level of each correlation). The data I have is the effect size of a treatment on these seven ...
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Can Composite Reliability (CR) be used for attenuation correction in meta-analysis?
I'm trying to conduct a meta-analysis on correlation using Spearman's disattenuation formula: rx'y' = rxy/sqrt(rxx*ryy). Can composite reliability (CR) instead of Cronbach's α be used in this formula? ...
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Do I have to redo my meta analysis?
I did a meta analysis of percentages using metamean in RStudio. Should I have used metaprop instead? For the SD argument in meta mean I used the SD for the binomial distribution.
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Computing Cohen's D directly from a Welch's t statistic
I'm performing a meta-analysis and am trying to extract a Cohen's $\hat{d}$ effect size measure from a paper; however the paper does not report any means or SDs. They do, however, report the results ...
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Meta-analysis of survival probabilities from single-arm studies
I am performing a meta-analysis of survival outcomes (expressed as % progression-free survival or overall survival at 1/2 years) from single-arm studies. I am using R package 'meta' with function '...
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How to calculate the effect sizes for a meta-analysis if a RCT study reported the correlation coefficient using partial pearson corrleation analysis?
I am currently performing a meta-analysis focusing on investigating the changes in variable A following weight loss. To address this, I have included studies that provide pre-and post-intervention A ...
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Studies with inconsistent value formats in a systematic review
I am conducting a systematic review and would like to report the mean of a value that is consistently reported in the studies I've included.
However, some studies report the value as a range (e.g., &...
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What does a non-significant intercept mean in a meta-regression using rma.mv ? Does it indicate problems? If so how to solve them?
I am conducting a meta-analysis using the metafor package in R. More specifically I use a random effects model applying the rma.mv function. When I run my meta-regression with moderators, I always get ...
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How to combine multiple odds ratio from different time points
I am doing a meta-analysis where my size effect is the odds ratio.
There is a study with multiple odds ratios for different times.
For example: I want the odds ratio for positive UDS for the intake of ...
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Network meta-analysis with placebo only comparison
I have a network meta-analysis where all treatment are compared to placebo.
Obviously this is not properly a disconected network but consistency cannot be assessed.
Is it problematic?
