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Questions tagged [meta-analysis]

Methods focused on contrasting and combining results from different studies, in the hope of increasing precision and external validity.

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Multivariate meta-analysis without individual patient data

Here is what I have. I have the results of 20 studies ($i=1,\dots,20$). For each study $i$, I have 6 outcomes $y_{ij}$ ($j=1,\dots,6$) and the within-variance of outcome $j$ in study $i$ $\sigma_{ij}^...
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Averaging Meta-Analytic Correlations?

I am conducting meta-analytic SEM and interested in looking at one outcome. A previous meta I was going to use as part of my data reports meta-analytic correlations for this outcome, however it is ...
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Coding of cross-over study's effects in a meta-analysis

One of the studies to be included in my meta-analysis has a cross-over design: between T1 and T2, a first group does the treatment condition while a second group does the control condition; and vice-...
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COMPARISONS OF ODDS RATIOS

For example, if I have 3 different trials each for 3 different drugs and I used meta analysis (sub group analysis) to generate effect sizes. How can I interpret the effect sizes? All drugs are being ...
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1answer
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INDIRECT COMPARISONS BETWEEN MULTIPLE DRUGS [closed]

So I have conducted a project involving 5 different drugs. There are no head to head trials between them. Only trials comparing these drugs to placebo. I have tried to pick trials where the patient ...
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1answer
27 views

INDIRECT COMPARISONS

I am conducting a project where I comparing a 5 different drugs (anti-psychotics) for a particular treatment group. There are currently no head-to-head trials for me to be able to make direct ...
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18 views

how to compare two interventions when one treatment improves an outcome while other worsens it

I need help with meta-analysis Description- we have two types of medical treatments- A & B across multiple trials. I'm trying to calculate cumulative odds ratio of an adverse event happening ...
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1answer
42 views

Heterogeneity test in meta-analysis

In a random effect meta-analysis model with one categorical independent variable $\theta_{ij}=\theta_i+s_j+\epsilon_j$, where $\theta_{ij}$ is the observed effect size in category $i$ in study $j$, $\...
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Comparing Meta-Analysis of identical studies

I'm doing an extracurricular programme at my university as part of which we have to write a review article. My supervisor agreed to a meta-analysis. I want to investigate whether the preprocessing of ...
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Can we perform meta-analysis of successive but independent studies?

I measured a variable $X$ and estimated the error bars on my measurement with the objective of testing if $X$ is significantly different from zero. I concluded that $X$ is different from zero only at ...
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Meta analysis: Pooling hazard ratios of continuous vs. dichotomous parameters?

I have a question regarding pooling hazard ratios derived through different means for a meta-analysis. Software: RevMan 5; Method: generic inverse variance (log hazard ratios). My issue is that some ...
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What does the decomposition of a relative risk look like?

Say I have a relative risk of smokers that smoked 1-20 cigarettes per day. What is the mathematical identity between that RR, the RR of those that smoked 1-10 cig/day, and RR of those that smoked 11-...
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How can you meta-analyse continuous and binary repeated measures outcome data?

Context: the random effects meta-analysis is of studies that measure visits to the doctor (visits), as a continuous variable (by reporting mean visits and respective standard deviations) or as a ...
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3answers
80 views

can I work out *the* standard deviation from a value given as “+/- 1 standard deviation”

I'm confronted by a table of values: 17.1 (16.6) 18.0 (9.5) 38.1 (22.5) 30.6 (16.7) In the left-hand column we have some mean values. I’m told that the values ...
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1answer
53 views

Network meta-analysis of correlation coefficients: a logical paradox?

A colleague of mine wishes to conduct a network meta-analysis of correlation coefficients for a set of imaging tests (eg ultrasound, computed tomography, magnetic resonance imaging, and so forth). ...
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2answers
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PRISMA Statement: number of records returned by (one/several) databases?

In keeping with the guidelines of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Statement, I am trying to fill in their flowchart (Fig. 1) with the details of the ...
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Combine group studies and case-studies in the same meta-analysis?

I heard from colleagues that case studies and group studies are typically not grouped together in the same meta-analysis. Several papers discuss the topic of which type of studies are "combinable" (e....
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Heterogeneity in meta-analysis studies: pooling across, vs separate analyses

The therapeutic intervention whose effect I need to meta-analyse has several regional variants, that amount to small-to-medium differences in how the therapy is administered to patients. Now, there ...
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IPD meta-analysis: need to weight regression and population level estimates?

Using individual patient data (IPD) from various studies, do I need to weight observations in a meta-analysis? Each study used a two-stage cluster sampling design with uniform samples per cluster and ...
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Why does finding small effects in large studies indicate publication bias?

Several methodological papers (e.g. Egger et al 1997a, 1997b) discuss publication bias as revealed by meta-analyses, using funnel plots such as the one below. The 1997b paper goes on to say that "...
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Meta analysis of multiple IV-regressions

For simplicity let us consider a single output Y and a single endogenous regressor of interest S. Suppose we have run multiple experiments over different periods in time, where we in each experiment, ...
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1answer
22 views

Idiosyncratic features of studies to be meta-analysed

I am working on a meta-analysis to assess the effect of a given speech therapy. Most papers (primary studies) use endpoints/outcomes that are standard for the intervention under scrutiny (speech ...
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Running a Multilevel Linear (Mixed-Effects) Meta-Analysis Model without a variance-covariance matrix

I have a dataset that I want to run a meta-analysis on. However, the data has a hierarchical structure with several endpoints per study and where studies are further clustered together. So, I should ...
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Robust meta-analysis with robumeta package in R

I used the samples' mean ages as a moderating variable for a meta-analysis on the relationship between two variables. I used the robumeta package and I found the mean age in 20 of the 21 studies (the ...
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1answer
33 views

Correlation meta-analysis of multiple paired mean data sets

I'm aware that it isn't possible to calculate a correlation coefficient from the means of two data sets. However, I'm wondering if there is a way to get a correlation coefficient (with confidence ...
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0answers
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Power calculation for TSSEM or Meta-analytic SEM

I am wondering about power calculations for Cheung's metaSEM/TTSEM. I assume Stage 2 SEM is where having too few studies/small sample sizes becomes problematic. Is there a way to run an a priori ...
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2answers
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Is it worth doing (single-armed) meta analysis if the studies' heterogeneity is very large?

I'm currently trying to perform a single-armed meta analysis of immunotherapy on breast cancer, which I believe this meta analysis will be the first among its intervention and cancer subtype. The ...
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1answer
25 views

How to calculate the Standard error on a meta-analysis

I have randomly broken down a very large dataset into 20 equal-sized blocks. I have fit a logistic model with random effects on each block with R (lme4). Say my model is simply: ...
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Choosing the measure of effect size to extract&summarise in a meta-analysis

I am preparing a meta-analysis for a certain therapeutic intervention, and will be interested to quantify/summarise the change in various scores, pre-to-post intervention. Which measure of effect ...
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Internal meta-analysis of sequential indirect effects when DVs differ slightly

Background: In three studies, we have one independent dichotomous IV, two continuous mediators, and a continuous DV. Our a priori hypothesis is that there’s an indirect effect of the IV on the DV ...
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What heterogeneity test is appropriate for my study? And, what is the use of correlation between median PFS and median OS [duplicate]

I want to perform a meta analysis of a particular subjects of cancer. My effect sizes are Overall Response Rate (ORR), Disease Control Rate (DCR), Duration of Response (DOR), Progression-Free Survival ...
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1answer
30 views

Sample size needed when combining multiple t-tests

I am designing an experiment that tests a difference in means between two groups in which data points take very long to generate (1 month each). Accordingly, I'd like to run several tests of the same ...
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1answer
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What to do in meta-analysis if confidence interval not symmetrical?

I'm about to make a meta analysis of a particular topic. I'm using Comprehensive Meta-Analysis (CMA) ver. 3.0 for that reason. However, after I input all the necessary data, the software refused to ...
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38 views

Calculating SMD

Is it possible to calculate SMD when the only data reported is the mean scores before and at end of study, for intervention and control groups, along with significance levels? This is how the data ...
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23 views

How to conduct a meta-analysis combining change data and absolute measurement data?

I am new to meta-analysis. I am looking at the psychological symptoms that develop in healthy people when given a drug versus placebo. Different measurement scales are used -so I need to use SMD. ...
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37 views

How to perform single-arm meta-analysis

I'm currently intending to perform a single-arm meta-analysis which study outcomes are: Objective Response Rate (ORR%), Disease Control Rate (DCR%), Duration of Response (DOR) in months, PFS in months,...
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variance explained in measurement error model

I have a seemingly simple problem that I struggle to find a solid answer to. Any hints on how to solve this--or indeed of good sources containing a discussion of this issue--would be highly ...
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1answer
14 views

How to perform a meta-analysis with combination of single and multiple groups

I am intending to perform a meta-analysis to analyze efficacy and safety profile of particular intervention. However, out of 9 studies included, some of them consists of a single group (experimental ...
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34 views

Simulating survival meta-analysis data (with a random effect) [closed]

I would like to simulate survival meta-analysis in clinical trials on R but I'm not pretty sure of what would be the best way to do it and what would be fitting more the reality. The data would ...
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1answer
25 views

A few questions about the calculations behind the metabin function, part of the R 'meta' package for meta analysis of binomial data

I am new to meta analysis, and am reading about how to perform meta analysis with binomial data. I'm looking for some clarification on some of the results given by the metabin function, which is part ...
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Different estimates in multilevel meta-analysis for categorial moderator vs. subgroup analysis

I am conducting a three-level meta-analysis using metaSEM in R. I want to find out the mean effect size for four subgroups of my dataset and later I also want to use these groups as a moderator. My ...
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4answers
35 views

How to combine multiple dose levels in a study for meta-analysis

I am conducting a meta-analysis of RCTs for treatment A vs. control. Some of the studies have multiple dose levels of A. Should I combine these groups with different doses of A and compute one effect ...
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Penalized Complexity Priors in meta4diag

I am currently in the process of running a diagnostic accuracy meta-analysis of sensitivity and specificity values. I am using the R program meta4diag, which uses a Bayesian model. As part of this ...
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2answers
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Can one perform a meta analysis on solely the results of a study, without the use of raw data? [closed]

If not, since a systematic review would be the next option, are there any analyses you can conduct on the results of the studies that one intends to analyze
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How do I code the interaction between a continuous and a categorical variable in a meta-analysis?

I'm currently coding studies for my meta-analysis and I was wondering how I should code the interaction between a categorical variable (1 = private, 2 = public, 3 = misc [both]) and a continuous ...
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1answer
29 views

In meta-analysis Q-statistic, is there a better way to compute the degrees of freedom?

I am working with a meta-analysis, and attempting to quantify heterogeneity across several data sources. I am using the following formula: $Q = \sum_i(w_i \cdot (y_i - \mu_F)^2)$ where $y_i$ is the ...
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0answers
55 views

Fixed or random effects in a subgroup analysis where heterogeneity is present in one of the subgroups but not the overall pooled result?

I am looking at a meta-analysis where a subgroup analysis has been performed, as it is important to consider the treatment effect within 2 subgroups of interest, as well as the overall pooled result. ...
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1answer
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interpretation of meta-regression in meta-analysis for number of participants explanatory variable

I have a meta-analysis with continuous variables, the melhroz study which I defined in the following dataframe ...
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1answer
91 views

Calculate sample variances from linear regression model for meta analysis?

I want to perform a meta analysis in two levels using linear regression in R (with lm() ). I understand that in the second level I should perform a weighted ...
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Question on a particular step in the Paule-Mandel 'Consensus Values and Weighting Factors' paper

I am preparing to use the Paule-Mandel method for determining the weighting factors in a meta-analysis. The paper I'm reading is the original one available here. I believe only those who are ...