# Questions tagged [meta-analysis]

Methods focused on contrasting and combining results from different studies, in the hope of increasing precision and external validity.

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### Weighted correlation with uncertainty on both groups

I want to estimate the correlation between two studies, which studied the same variables in two different conditions. For each variable I have an estimate (b), standard error (se) and p-value (p). ...
2answers
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### Meta-analyzing incidence (count) data with many zero cells

I am conducting a meta-analysis on the incidence of a rare event. I have 15 single-arm studies with events occurring in only 2 studies. The metarate function in the meta package allows for meta-...
0answers
25 views

### What data type is needed for a meta-analysis?

I have a student who has compiled field data from agricultural studies across parts of Africa. She wants to conduct a meta-analysis to determine if cropping system type is having an impact on crop ...
0answers
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### Converting unstandardised regression coefficients to Cohen's d for meta-analysis

I am conducting a meta-analysis of Cohen's d and some raw effect sizes are unstandardised regression coefficients. Of these unstandardised regression coefficients: Some are based on a binary ...
1answer
990 views

### Interpretation when converting correlation of continuous data to Cohen's d

A popular textbook on meta-analysis (1) discusses how to convert a correlation, $r$, to Cohen's $d$ (i.e., the standardized mean difference): I became confused about how to interpret the resulting $d$...
1answer
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### Test for Subgroup Difference Compared to Test for Moderator

I have performed a proportional meta-analysis to evaluate the rate of procedural success for two medical procedures. The two procedures comprise the two subgroups in my meta-analysis (FNA and FNB). I ...
0answers
16 views

### Interpreting effects in a meta analysis random intercepts regression model

I have a random intercepts model with two different clustering levels: studies and countries within which these studies were made. So, my interest is to estimate a model to figure out the grand mean ...
0answers
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### Outlier Detection in Meta-Analysis Models for Observational Studies of Adverse Drug Outcomes using Distributed Networks

I hope you are in good health. My thesis is on outlier detection in meta-analysis models. I will be using a case study from Canadian Network for Observational Drug Effects Studies (CNODES) to detect ...
0answers
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### Why is my standard error for the treatment effect is not giving the right 95% confidence interval in R (meta package)?

I am trying to do a meta-analysis using risk ratio, lower and upper 95% confidence interval in meta package in R but for example, M study, obtained upper and lower 95%CI ([0.7162; 1.1690]) were ...
2answers
162 views

### Why am I getting different means when conducting multilevel meta-analysis with factorial moderator vs. as subgroups?

I already asked about this in stackoverflow but maybe it fits better here. I want to conduct a multilevel meta-analysis using metafor in R. I have effect sizes ("esid") nested within samples ("...
0answers
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### What method for analysis of pooled data (continuous variable) [closed]

I sought to perform meta analysis of continuous variables I have extracted mean and SD from multiple studies for a variable What is the statistical method to compute a "global" mean + SD ...
1answer
245 views

### Is Meta Analysis the Future of Bayesian Statistics?

Is Meta Analysis the Future of Bayesian Statistics? To summarize these two concepts: Bayesian Statistics involve using historical information about the distribution of model parameters to supplement ...
2answers
1k views

### Meta-analysis in R with multiple SNPs

I'm conducting a meta-analysis on two genome wide association studies (GWAS), each consisting of 150 SNPs, for which I computed summary statistics for association. I'm using the R package meta and the ...
0answers
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### Predicted treatment effect for causally related conditions

Let's say there are two medical conditions $A$ and $B$ that are causally-related, i.e. that they share a common etiological process $C$. For example, $A$ and $B$ could be related autoimmune conditions ...
1answer
38 views

### What to do with missing effect sizes in meta-analyses?

I'm currently working on a meta-analysis but I'm unsure what to do with missing effect sizes. Effect sizes in my dataset may be missing for two reasons: The effect size is non-significant and the ...
0answers
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### How to conduct a meta-analysis on ICCs (i.e., test-retest reliability)?

I have calculated two-way single consistency ICCs in R using the irr package. There are multiple ICCs representing test-retest reliability across these time points. Is there a way to compute a meta-...
0answers
13 views

### Pooling in a Meta Analysis

I am looking to pool data for adverse events for a meta analysis and I wanted to see if my plan made sense I want to pool my AE together based on the Clavien Dindo categorizations, as this will make ...
0answers
19 views

### Adding Cumulative Means and Variances

I would like to get cumulative data about opioid use after surgery on day 2 of use. I have the mean, SD for day 1 and for day 2. My understanding for the means is I can add them together. When it ...
1answer
21 views

### "Media" as a measure of central tendency

I've just read a meta-analysis that used 'media' as a measure of central tendency: "The media of skin side events related to PPE was 75.13%". I've never come across the use of "media&...
1answer
2k views

### Comparing effect sizes across different data sets with non-normal data

I want to conduct a comparative analysis across a large amount of studies by looking at the effect sizes of their results with another variable. I am not too familiar with effect sizes so I'd ...
2answers
278 views

### hazard ratio: are they normally distributed?

I am looking at forest plots (in the context of meta-analyses of clinical trials). I see values for hazard ratios, together with 95% confidence interval. My question: to compute this confidence ...
0answers
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### Combine group studies and case-studies in the same meta-analysis?

I heard from colleagues that case studies and group studies are typically not grouped together in the same meta-analysis. Several papers discuss the topic of which type of studies are "combinable" (e....
1answer
414 views

### Stratified logistic regression with log link

I noticed the other day that I can mimic a stratified logistic regression using a meta-analytic approach at least when there is only one stratification variable with two different values. This is the ...
0answers
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### Phased Trial and Meta-Analysis [closed]

I'm currently conducting a meta-analysis of pharmacist-led health interventions and their effect on levels of medication adherence. One of my studies has a phased intervention design. This means that ...
0answers
14 views

### Can I pool studies in a meta analysis with binary and continuous outcomes? [duplicate]

I'm currently completing a meta-analysis (in r using the meta/metafor package) looking at predictors of treatment response in patients suffering from a particualr mental disorder (psychosis). Some ...
2answers
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### A reasonable choice of effect size for a meta-analysis

I'm doing a meta-analysis where the studies ask the study participants to read, find, and correct the wrong words in a text. Some studies score each study participant's performance on the text using: ...
0answers
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### How to get 'overall' numbers in forest plot in meta analysis using STATA [closed]

I am trying to perform a meta-analysis. I put together the data, and I am creating a forest plot. I have several questions regarding how I can change the figure created by STATA. 1- After the studies ...
1answer
25 views

### comparing effect sizes (partial correlations) for multiple outcomes in a meta-analysis

I'm conducting a meta-analysis using the metafor package. I'm using partial correlations and I'm interested in two effects - correlations between X and Y1 and X and Y2 (both controlling for Z). I have ...
0answers
19 views

### Meta analysis Hazard Ratio with small number of studies (n=2)

I am doing a fixed effect meta-analysis pooling hazard ratios from 2 very similar cohorts. I understand that the inverse variance method is most commonly used to pool HR, however I also read that this ...
1answer
57 views

### What is the new sample size of a within study summary effect for outcomes with different sample sizes?

I am performing a meta-analysis and want to compute a summary effect (i.e. weighted mean) for studies that report data on more than one effect size. The same participants are involved, however the ...
1answer
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### What is the justification for weighting meta-analysis by standard error instead of sample size?

I have observed in many meta-analyses, and in tutorials on the matter, that the analyzed studies are commonly weighted by the reciprocal of the standard error. This seems to have a face validity ...
0answers
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### Determining the standard deviation based on standard deviations from 2 data sets (paired)

I would like to run an analysis on the effectiveness of a drug on a specific parameter. In 1 study, mean and SD values were reported at baseline, and post-treatment for both experimental and control ...
1answer
37 views

### Interpret Generalized linear mixed model output

I've built a generalized linear mixed model due to non-normal data (no transformation will make it normal). I'm new to mixed models and I'm unsure how to report the output in a paper. Here is the ...
1answer
971 views

### Easy post-hoc tests when meta-analyzing with the metafor package in r

I am conducting meta-analysis using metafor in R. I would like to compare among 7 levels in a factor (i.e. different types of treatments). ...
0answers
21 views

### How to weigh a precomputed effect estimate according to its sample size in a meta-analysis?

I am currently conducting a meta-analysis in R with the intent to pool a standardized metric (i.e. defined daily dose (DDD) per 1000 inhabitant days) into a single forest plot. None of the studies ...