Questions tagged [meta-analysis]

Methods focused on contrasting and combining results from different studies, in the hope of increasing precision and external validity.

Filter by
Sorted by
Tagged with
1
vote
0answers
8 views

How can I calculate the sample size of self-control study design for a two-arm meta-analysis

I recently encounter with a question is that I want to perform a traditional two-arm meta-analysis, however, some of the included studies are self-controlled study design. The natural way to deal this ...
2
votes
0answers
22 views

How do we call the distribution of a ratio consisting of a constant divided by a truncated normal random variable?

I have been thinking for a while about the following problem of Cohen's d effect size measure $d={\frac {\mu _{1}-\mu _{2}}{\sigma}}$ in random-effects meta-analyses for which I cannot find a more ...
2
votes
2answers
87 views

Why did meta-learning (or model stacking) underperform the individual base learners?

I want to use meta-learning, specifically, stacking to combine the results of two algorithms, denoted here A and B. The results of A and B correspond to the first and second columns in the dataset '...
1
vote
0answers
32 views

Meta-analysis - no control groups!

I am conducting a meta-analysis of volumetric growth rates of a specific tumour type, per year, after surgery. The studied included have no control groups, but rather arms of interventions. I am ...
2
votes
0answers
22 views

Multi-Level Modelling in Metanalysis where effect size is in percentage

I was wondering if someone can help. I have a meta-analysis where I have 5 outcomes and 10 included studies. The studies are classic prevalence/ epidemiological studies, so not 2 groups. I want to ...
1
vote
0answers
31 views

Meta-analysis of data with no standard deviation

I am carrying out a Meta-analysis on the impacts of forest logging on Soil. One of the parameter which I want to investigate is the qbs-ar index, which is a index of soil biological quality. This ...
1
vote
1answer
53 views

Do Odds Ratios (OR) have a similar ranking categorisation as Cohen's conventions?

I'm trying to meaningfully interpret the findings from this meta-analysis which states: "Additional evidence supported the association between fever during pregnancy and increased risk for NDD in ...
1
vote
0answers
23 views

Sensitivity analysis on secondary outcome

I plan to perform a meta-analysis with a primary outcome consisting in very rare events (sometimes not occurring in any group of some studies included), and a much more frequent secondary outcome. To ...
3
votes
0answers
29 views

Combining Time-Defined Hazard Ratios and Odds Ratios in Meta-Analysis

I am attempting to complete a meta-analysis of studies that variously report Odds Ratio of death at 30 days, and Hazard Ratios for death at 30 days. All are reported as being close to 1 (range 1.2-1....
2
votes
1answer
34 views

Random effects model for meta-analysis of rare events

The Cochrane Handbook states that incorporation of heterogeneity into an estimate of a treatment effect should be a secondary consideration when attempting to produce estimates of effects from sparse ...
2
votes
0answers
29 views

Statistical test for rare events in meta-analysis

As a pedagogical work, I am planning to perform a meta-analysis with a rare event as the primary outcome. Here is the type of data I plan to collect (the numbers here are fictive): study no. events ...
3
votes
1answer
21 views

Analysing non-outcome variables in meta-analysis

I am working on a meta-analysis project in suicidology. This is more like an academic exercise and will not necessarily be submitted for publication, but I try to be as rigorous as possible. Now here ...
1
vote
0answers
50 views

Averaging time-dependent, heteroscedastic estimates of vaccine efficacy over time periods

Vaccine efficacy against Omicron has to be estimated for three months since the second dose. Efficacy data are given for shorter periods comprising three months. For example, the table, based on Fig ...
1
vote
0answers
23 views

Considering sample size as controlling factor in meta-regression

In a meta-regression, authors have 3 explanatory variables of interest for 2 countries. But all these three variables were not present in all those studies which were finally selected for meta-...
1
vote
1answer
21 views

Usage of metafor package - order of terms

My question might be too simple but I couldn´t figure out the answer online or by only reading the help function of metafor package. While conducting a meta-analysis trough escalc function what is the ...
1
vote
0answers
17 views

meta study of beta distributed posteriors

I have run 10 studies where my variable x has a beta distribution (it's between 0 and 1). I now want to infer a global/meta distribution from the local studies. Let's say I can estimate posterior a ...
1
vote
0answers
23 views

【R】How can I interpret the fixed effects of multiple combined variables using "feols" function in "fixest" package? [closed]

I am now doing regression by using "fixest" package in R. Especially, "feols" function. I do so by incorporating mutltipled comibined variables as a fixed effect. Examples are ...
1
vote
0answers
15 views

Weighted correlation with uncertainty on both groups

I want to estimate the correlation between two studies, which studied the same variables in two different conditions. For each variable I have an estimate (b), standard error (se) and p-value (p). ...
1
vote
0answers
28 views

What data type is needed for a meta-analysis?

I have a student who has compiled field data from agricultural studies across parts of Africa. She wants to conduct a meta-analysis to determine if cropping system type is having an impact on crop ...
1
vote
2answers
28 views

Meta-analyzing incidence (count) data with many zero cells

I am conducting a meta-analysis on the incidence of a rare event. I have 15 single-arm studies with events occurring in only 2 studies. The metarate function in the meta package allows for meta-...
2
votes
0answers
94 views

Converting unstandardised regression coefficients to Cohen's d for meta-analysis

I am conducting a meta-analysis of Cohen's d and some raw effect sizes are unstandardised regression coefficients. Of these unstandardised regression coefficients: Some are based on a binary ...
1
vote
1answer
23 views

Test for Subgroup Difference Compared to Test for Moderator

I have performed a proportional meta-analysis to evaluate the rate of procedural success for two medical procedures. The two procedures comprise the two subgroups in my meta-analysis (FNA and FNB). I ...
1
vote
0answers
17 views

Interpreting effects in a meta analysis random intercepts regression model

I have a random intercepts model with two different clustering levels: studies and countries within which these studies were made. So, my interest is to estimate a model to figure out the grand mean ...
1
vote
0answers
14 views

Outlier Detection in Meta-Analysis Models for Observational Studies of Adverse Drug Outcomes using Distributed Networks

I hope you are in good health. My thesis is on outlier detection in meta-analysis models. I will be using a case study from Canadian Network for Observational Drug Effects Studies (CNODES) to detect ...
2
votes
0answers
47 views

Why is my standard error for the treatment effect is not giving the right 95% confidence interval in R (meta package)?

I am trying to do a meta-analysis using risk ratio, lower and upper 95% confidence interval in meta package in R but for example, M study, obtained upper and lower 95%CI ([0.7162; 1.1690]) were ...
1
vote
0answers
19 views

What method for analysis of pooled data (continuous variable) [closed]

I sought to perform meta analysis of continuous variables I have extracted mean and SD from multiple studies for a variable What is the statistical method to compute a "global" mean + SD ...
3
votes
1answer
255 views

Is Meta Analysis the Future of Bayesian Statistics?

Is Meta Analysis the Future of Bayesian Statistics? To summarize these two concepts: Bayesian Statistics involve using historical information about the distribution of model parameters to supplement ...
1
vote
0answers
17 views

How to conduct a meta-analysis on ICCs (i.e., test-retest reliability)?

I have calculated two-way single consistency ICCs in R using the irr package. There are multiple ICCs representing test-retest reliability across these time points. Is there a way to compute a meta-...
1
vote
1answer
40 views

What to do with missing effect sizes in meta-analyses?

I'm currently working on a meta-analysis but I'm unsure what to do with missing effect sizes. Effect sizes in my dataset may be missing for two reasons: The effect size is non-significant and the ...
2
votes
0answers
13 views

Pooling in a Meta Analysis

I am looking to pool data for adverse events for a meta analysis and I wanted to see if my plan made sense I want to pool my AE together based on the Clavien Dindo categorizations, as this will make ...
3
votes
0answers
20 views

Adding Cumulative Means and Variances

I would like to get cumulative data about opioid use after surgery on day 2 of use. I have the mean, SD for day 1 and for day 2. My understanding for the means is I can add them together. When it ...
2
votes
1answer
23 views

"Media" as a measure of central tendency

I've just read a meta-analysis that used 'media' as a measure of central tendency: "The media of skin side events related to PPE was 75.13%". I've never come across the use of "media&...
2
votes
0answers
76 views

Predicted treatment effect for causally related conditions

Let's say there are two medical conditions $A$ and $B$ that are causally-related, i.e. that they share a common etiological process $C$. For example, $A$ and $B$ could be related autoimmune conditions ...
1
vote
0answers
14 views

Can I pool studies in a meta analysis with binary and continuous outcomes? [duplicate]

I'm currently completing a meta-analysis (in r using the meta/metafor package) looking at predictors of treatment response in patients suffering from a particualr mental disorder (psychosis). Some ...
1
vote
0answers
23 views

Meta Analysis: how to compare RR, OR, HR

I have a 5 study dataset with 2 IRRs, 2 ORs and 1 HR, all with CIs given. Can I do a log transformation and then conduct a meta analysis. What is a plausible way to conduct meta analysis in this case
1
vote
1answer
19 views

Raw data reanalysis of multiple studies consider as meta analysis?

I am struggling with the question of how to define my research. I download raw data (RNA sequencing data) from multiple studies and I am going to analyze again them together as they " brought ...
2
votes
0answers
39 views

Ratio of means for a medical meta-analysis

I am in the process of pooling and analysing data from various studies for a meta-analysis I am working on. My supervisor (non-statistician) is keen for us to have the ratio of means which was ...
1
vote
1answer
39 views

How to back-transform regression coefficients in a multi-level meta-regression in metafor

My question is an extension of this one, where I asked about back-transforming the results of a reliability generalization meta-analysis. I have run a three-level meta-regression, using the Bonett-...
3
votes
2answers
266 views

Why is there a discrepancy between the underlying meaning of variance between basic statistics and meta-analyses?

Normally, I would say that variance (and, in extension, standard deviation since it's just the square root of the variance) refers to a measure of deviation that describes how data points within a ...
1
vote
2answers
46 views

I want to test for a significant difference in the result (t-value or effect size) of two paired t-tests

I am testing the quality of a measurement construct, where I propose that Measure A is better (i.e. more responsive to situational changes) than Measure B is. I conduct a study in which I measure the ...
1
vote
0answers
19 views

Can I pool together data from two seperate RCTs of the same intervention when I have access to both datasets? If so, what analysis is appropriate?

Background I have available the data from: A parallel arm RCT of Intervention A compared to a control group that was conducted several years ago. The primary outcome is a difference in the post-...
3
votes
1answer
32 views

Is there a method/package that combines multivariate and network meta-analysis?

If you want to perform a meta-analysis on the general strength of the population and where each study can offer multiple outcomes (for example, measuring strength through deadlift capability and/or ...
1
vote
0answers
25 views

A reasonable choice of effect size for a meta-analysis

I'm doing a meta-analysis where the studies ask the study participants to read, find, and correct the wrong words in a text. Some studies score each study participant's performance on the text using: ...
4
votes
2answers
190 views

Calculate the standard deviation from a hazard ratio's confidence interval

I often come across hazard ratios and their confidence intervals in the published literature on clinical trials. I would like to calculate the standard deviation from these confidence intervals for ...
1
vote
0answers
17 views

How to get 'overall' numbers in forest plot in meta analysis using STATA [closed]

I am trying to perform a meta-analysis. I put together the data, and I am creating a forest plot. I have several questions regarding how I can change the figure created by STATA. 1- After the studies ...
3
votes
1answer
26 views

comparing effect sizes (partial correlations) for multiple outcomes in a meta-analysis

I'm conducting a meta-analysis using the metafor package. I'm using partial correlations and I'm interested in two effects - correlations between X and Y1 and X and Y2 (both controlling for Z). I have ...
1
vote
0answers
19 views

Meta analysis Hazard Ratio with small number of studies (n=2)

I am doing a fixed effect meta-analysis pooling hazard ratios from 2 very similar cohorts. I understand that the inverse variance method is most commonly used to pool HR, however I also read that this ...
3
votes
1answer
61 views

What is the justification for weighting meta-analysis by standard error instead of sample size?

I have observed in many meta-analyses, and in tutorials on the matter, that the analyzed studies are commonly weighted by the reciprocal of the standard error. This seems to have a face validity ...
1
vote
0answers
19 views

Determining the standard deviation based on standard deviations from 2 data sets (paired)

I would like to run an analysis on the effectiveness of a drug on a specific parameter. In 1 study, mean and SD values were reported at baseline, and post-treatment for both experimental and control ...
1
vote
1answer
58 views

What is the new sample size of a within study summary effect for outcomes with different sample sizes?

I am performing a meta-analysis and want to compute a summary effect (i.e. weighted mean) for studies that report data on more than one effect size. The same participants are involved, however the ...

1
2 3 4 5
24