Questions tagged [meta-analysis]

Methods focused on contrasting and combining results from different studies, in the hope of increasing precision and external validity.

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24 views

What heterogeneity test is appropriate for my study? And, what is the use of correlation between median PFS and median OS [duplicate]

I want to perform a meta analysis of a particular subjects of cancer. My effect sizes are Overall Response Rate (ORR), Disease Control Rate (DCR), Duration of Response (DOR), Progression-Free Survival ...
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1answer
68 views

Sample size needed when combining multiple t-tests

I am designing an experiment that tests a difference in means between two groups in which data points take very long to generate (1 month each). Accordingly, I'd like to run several tests of the same ...
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1answer
185 views

What to do in meta-analysis if confidence interval not symmetrical?

I'm about to make a meta analysis of a particular topic. I'm using Comprehensive Meta-Analysis (CMA) ver. 3.0 for that reason. However, after I input all the necessary data, the software refused to ...
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66 views

Calculating SMD

Is it possible to calculate SMD when the only data reported is the mean scores before and at end of study, for intervention and control groups, along with significance levels? This is how the data ...
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28 views

How to conduct a meta-analysis combining change data and absolute measurement data?

I am new to meta-analysis. I am looking at the psychological symptoms that develop in healthy people when given a drug versus placebo. Different measurement scales are used -so I need to use SMD. ...
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200 views

How to perform single-arm meta-analysis

I'm currently intending to perform a single-arm meta-analysis which study outcomes are: Objective Response Rate (ORR%), Disease Control Rate (DCR%), Duration of Response (DOR) in months, PFS in months,...
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0answers
16 views

variance explained in measurement error model

I have a seemingly simple problem that I struggle to find a solid answer to. Any hints on how to solve this--or indeed of good sources containing a discussion of this issue--would be highly ...
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1answer
26 views

How to perform a meta-analysis with combination of single and multiple groups

I am intending to perform a meta-analysis to analyze efficacy and safety profile of particular intervention. However, out of 9 studies included, some of them consists of a single group (experimental ...
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0answers
42 views

Simulating survival meta-analysis data (with a random effect) [closed]

I would like to simulate survival meta-analysis in clinical trials on R but I'm not pretty sure of what would be the best way to do it and what would be fitting more the reality. The data would ...
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1answer
63 views

A few questions about the calculations behind the metabin function, part of the R 'meta' package for meta analysis of binomial data

I am new to meta analysis, and am reading about how to perform meta analysis with binomial data. I'm looking for some clarification on some of the results given by the metabin function, which is part ...
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33 views

Different estimates in multilevel meta-analysis for categorial moderator vs. subgroup analysis

I am conducting a three-level meta-analysis using metaSEM in R. I want to find out the mean effect size for four subgroups of my dataset and later I also want to use these groups as a moderator. My ...
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4answers
115 views

How to combine multiple dose levels in a study for meta-analysis

I am conducting a meta-analysis of RCTs for treatment A vs. control. Some of the studies have multiple dose levels of A. Should I combine these groups with different doses of A and compute one effect ...
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55 views

Penalized Complexity Priors in meta4diag

I am currently in the process of running a diagnostic accuracy meta-analysis of sensitivity and specificity values. I am using the R program meta4diag, which uses a Bayesian model. As part of this ...
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2answers
174 views

Can one perform a meta analysis on solely the results of a study, without the use of raw data? [closed]

If not, since a systematic review would be the next option, are there any analyses you can conduct on the results of the studies that one intends to analyze
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40 views

How do I code the interaction between a continuous and a categorical variable in a meta-analysis?

I'm currently coding studies for my meta-analysis and I was wondering how I should code the interaction between a categorical variable (1 = private, 2 = public, 3 = misc [both]) and a continuous ...
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1answer
32 views

In meta-analysis Q-statistic, is there a better way to compute the degrees of freedom?

I am working with a meta-analysis, and attempting to quantify heterogeneity across several data sources. I am using the following formula: $Q = \sum_i(w_i \cdot (y_i - \mu_F)^2)$ where $y_i$ is the ...
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0answers
146 views

Fixed or random effects in a subgroup analysis where heterogeneity is present in one of the subgroups but not the overall pooled result?

I am looking at a meta-analysis where a subgroup analysis has been performed, as it is important to consider the treatment effect within 2 subgroups of interest, as well as the overall pooled result. ...
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1answer
63 views

interpretation of meta-regression in meta-analysis for number of participants explanatory variable

I have a meta-analysis with continuous variables, the melhroz study which I defined in the following dataframe ...
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1answer
166 views

Calculate sample variances from linear regression model for meta analysis?

I want to perform a meta analysis in two levels using linear regression in R (with lm() ). I understand that in the second level I should perform a weighted ...
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0answers
25 views

Question on a particular step in the Paule-Mandel 'Consensus Values and Weighting Factors' paper

I am preparing to use the Paule-Mandel method for determining the weighting factors in a meta-analysis. The paper I'm reading is the original one available here. I believe only those who are ...
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0answers
50 views

three-level meta-analysis with dependency on two levels

I am conducting a meta-analysis on the effect of concientiousness on scholastic achievement in high-school students. Currently, I am struggling to find the right statistical analysis for my data ...
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0answers
132 views

How to use metafor if only Cohen's d and dz are available

I am looking for examples or suggestions how to use the R package metafor to conduct a meta-analysis if no descriptive statistics are available, only Cohen's ds and Cohen's dz, alongside the sample ...
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1answer
123 views

Meta-analysis with response ratio effect size

I am interested in comparing the performance of two different techniques (i.e., Method A vs. Method B) on a continuous outcome of interest. The performance of such techniques is measured through test ...
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0answers
34 views

Deriving heterogeneity measures for each level in a multi-level moderator meta-analysis

I'm running a multi-level moderator meta-analysis using the R package metafor. To derive $I^2$ for the metafor analysis as a whole, which doesn't come out ...
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0answers
75 views

Meta-analysis in metafor package with within-subjects standard error?

I am conducting a meta-analysis with metafor in R. For the majority of articles, I managed to extract means and standard deviations, which I need for the escalc function to calculate an effect size. ...
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1answer
176 views

Meta analysis Cliff's delta

Cliff's delta is an effect size typically recommended whenever the normality and homogeneity assumption do not hold---and thus, Cohen's d cannot be used. However, I cannot see any reference ...
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62 views

How to meta-analyze three effect sizes of correlations?

I am searching statistical approaches to analyze three effect sizes of correlations. I would like to see the relationships among one independent variable (performance on a certain type of cognitive ...
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0answers
162 views

How to compute effect sizes of single predictor in a logistical regression?

I have a logistic regression, with a binary response, a continuous predictor, and a categorical one. Is there any way to calculate the effect size of each of those predictors, similar to partial eta-...
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3answers
319 views

Calculating Standard Error of Tau - Meta Analysis

I am conducting a meta analysis using the metafor package in R and am trying to calculate the Standard Error (if possible) of the Tau statistic. The S.E of the tau-...
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1answer
51 views

The trouble with meta-analysing a small number of (homogeneous) single-case studies

I am considering doing a meta-analysis on the reported effects of a particular therapy. I've seen it suggested that the minimum number of studies (so far I identified k=7 of them) is not in itself a ...
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1answer
29 views

Comparing non-independent metaanalytic effect sizes

I am running a random-effects meta-analysis on a collection of placebo controlled trials. Each trial reports on the effects of the drug and placebo on 'positive symptoms' and 'negative symptoms'. I ...
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1answer
310 views

Bonferroni-type corrections and Fisher Method Meta-analysis

I'm not an expert on the field, but I need to know more about how to combined multiple significance test p-values after a two sample Kolmogorov Smirnov (KS)test on two distributions. But I have two ...
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1answer
69 views

Which R package or function to use for meta-analysis [closed]

I am interested in combining point-wise survival estimates from Kaplan-Meier curves, e.g. I want to combine the survival estimates at age 70. Which R package/functions should I look into? I see that ...
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1answer
356 views

Is meta-analysis of odds ratios essentially hopeless?

In a recent paper Norton et al. (2018)$^{[1]}$ state that Different odds ratios from the same study cannot be compared when the statistical models that result in odds ratio estimates have ...
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2answers
152 views

Output of metafor for incidence rates

I need to clarify something and am hoping Wolfgang or someone else with expertise in the metafor R package could help. I want to know what the output of the rma model (with a moderator in is for a ...
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1answer
40 views

Changing units of variance to match changed mean

I have a mean of hrs/day. I have converted this to mins/day (by multiplying by 60). However I am not sure what I should do with the SD or confidence intervals which refer to the variance of hrs/day. ...
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1answer
49 views

Network meta analysis without standard deviations

I am trying to compute Cohen's in some studies that I gathered in a Systematic Literature Review. Unfortunately, almost none of them report the standard deviation (nor df/t, or something for back-...
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0answers
144 views

Using metafor with multiple outcomes from single studies, and how to calculate within- and between-study heterogeneity?

I am currently conducting a meta-analysis where we have several studies that report multiple outcomes from the same participants. We've been advised to use the ...
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1answer
65 views

How can one get consistent (i.e. direct+indirect=total) effects in a Meta-Analytic SEM model with latent variables?

I have a mediation model with latent variables using datasets from a few studies. In particular, one of the latent variables is the outcome, while the others are tested as possible mediators of a ...
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0answers
121 views

Compute Becker's (1988) standardized mean change based only on difference score and t-statistic (meta-analysis)

In my meta-analysis, I'm combining independent-sample designs with single-group pretest-posttest designs. To ensure interpretability across designs, I would like to quantify the effects from pretest-...
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1answer
55 views

Assessing normality assumption of effect sizes in meta-regression

I'm considering options for estimating tau-squared (the true between-study variance) in meta-regression, and I know method-of-moments (MM), unrestricted maximum likelihood (ML) and restricted maximum ...
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0answers
30 views

Shouldn't we consider larger standard errors for effect measures or outcomes that are converted in meta-analysis?

There are methods to convert effect measures in meta-analysis (pdf). There are also methods to convert outcomes; at least, I am aware of the conversion described in Furukawa et al. (2005) from ...
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0answers
23 views

Meta-analysis of different binnings of the same continuous variable

I am conducting a meta-analysis in which household income is the IV. Unfortunately, for a variety of reasons, authors choose to operationalize income in a variety of ways. Some authors present ...
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1answer
86 views

Problem in accuracy when calculating p value from a 95% confidence interval

For my meta-analysis I have to obtain univariate analyses (HR, 95% CI, p value) from different studies. I came across one study with a given HR: 1.19 and 95% CI: 0.46 - 2.51. By surfing on the ...
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2answers
289 views

How to interpret heterogeneity in a meta analytic model

I try to fit a random effects model for my thesis, a meta analysis of studies about team planning and team performance. I'm using R and the package metafor to create z correlations and variance (yi, ...
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1answer
143 views

Odds ratio, Meta-analysis

I have the following for the data for the meta-analysis: OR , standard errors, logged OR , variance of logged OR I have generated a forest plots first using "OR" with "variance of logged OR" using ...
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0answers
44 views

Meta-analysis - effect size from multiple severity groups

I am currently performing a meta analysis to evaluate whether a measure (let's call it Meas) is correlated to the severity of a disease (Sev). The severity of the disease is reported as a score from 0 ...
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1answer
99 views

Can effect sizes (SES) be compared when the underlying null distributions are different in a meta-analysis?

Background: In community ecology one of the questions we are interested in is if the species in a community are non-randomly associated. To try and get at this we typically use a null modelling ...
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1answer
30 views

If someone wanted to do a meta analysis would they be able to use a publication that does not have p-values listed in the publication?

If someone wanted to do a meta analysis would they be able to use a publication that does not have p-values listed in the publication? Does a meta analysis really need a publication to have a p-value?...
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1answer
51 views

Type of studies reviewed in meta-analysis of proportion

What types of studies are reviewed for meta-analysis of proportions? For example can I included case-control studies and collect data of number of events from the total cases?

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