Questions tagged [meta-regression]

A meta-analytic tool that examines the impact of moderator variables on studies' effect size. It is another name for mixed effects model in meta-analysis (moderators are fixed effects, studies are random effects).

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Meta-analysis based on cohort studies only

I am planning a meta-analysis based on cohort studies only. There are dozens of papers reporting results of treatments A and B. But the treatments were never compared with each other. Besides, there ...
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Comparing Multi-level Meta-regression to Network Meta-Analysis for Dose-response Project

I am planning a meta-analysis to examine the average change in a continuous variable over time within my area of research. To be able to meta-analyze this continuous relationship, I've typically ...
zr2015's user avatar
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Which prediction interval to use - meta-regression selected using LOOCV

I have a research paper that conducted a meta-regression using multiple predictor variables in metafor. They did a meta-regression for all combinations of variables and then used LOOCV to select the ...
Aaron Simmons's user avatar
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Estimating mean and prediction intervals for new predictions using meta-regression output

Let's start with linear regression. You develop a simple linear regression equation $y = ax + b$. You can predict $\hat{y}_h$ for $x_h$ and estimate the prediction intervals using $$\hat{y}_h \pm t_{\...
Aaron Simmons's user avatar
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Including covariates in a multivariate multi-level meta-analysis

I am carrying out a multivariate multi-level meta-analysis, and I have a question regarding including moderator variables in the context of publication bias. Doucouliagos and Stanley (2009) recommend ...
Daniel's user avatar
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Combining meta-analysis and machine learning (accounting for heterogeneity)

What are the standard methods for training machine learning algorithms on data, issued from multiple studies? In conventional meta-analysis one usually uses weighted average to combine estimates ...
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How to conduct meta analysis for studies that have used repeated cross section surveys to report prevalence

When conducting meta-analysis on prevalence of disease, few studies have reported prevalences using different rounds of cross-sectional surveys. When analyzing such studies shall I take each reported ...
siri's user avatar
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How to interpret a meta-regression output?

I've conducted meta-regression analyses using the 'metafor' package in R. I am trying to interpret the outputs if you could please help? Output 1 (categorical with 3 levels): Test of moderator is ...
Helen's user avatar
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How to compare and summarize continues and factorial designed experiments?

I am new here so I hope this question is expressed properely. I would like to compare a summary of factorial ordinal experiments with e.g., 4 concentrations to studies using a continues vector IV. To ...
WrapUp's user avatar
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1 answer
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Meta analysis: can multiple test corrections (i.e. Bonferroni) be applied on the pooled effect p-value?

I plan to do a meta-analysis including the effect size of each cohort as the objectives. I'd like to ask if I could apply multiple test corrections (i.e. Bonferroni) on the pooled effect p-value. I ...
Joe's user avatar
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Including study as a moderator in a meta-analytical model

I'm trying to figure out what it means to include 'study' as a moderator in a meta-analytical model. In the R package metafor, for example, we might build an intercept-only random effects model as ...
befriendabacter's user avatar
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Meta-Regression with BDI mean difference as a predictor?

I am conducting a Meta-Analysis using metafor in R. I calculate the standardized mean difference between patient groups (PG) and ...
benjarmin1's user avatar
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What is Bsum in (meta-)regression and how do you test for its significance?

I received a reviewer report on a meta-analysis that I submitted which stated that a multivariate regression that I performed should instead be "a backward stepwise multivariate logistic ...
vladbadu's user avatar
1 vote
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29 views

How can I calculate the power (number of studies) needed for a meta-regression?

I would like to know how small of a beta coefficient my meta-regression is powered to detect. Thank you for any help.
M BG's user avatar
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Approaches to (non-linear) meta-regression to estimate the conditional population distribution of $y$ based on aggregate data

I want to estimate the distribution of a variable in certain subgroups of the population based on pooling of aggregate data reported in various observational studies. For simplicity, assume there is a ...
user9794's user avatar
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1 answer
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Can you meta-analyze multiple outcomes of a single experiment?

Suppose there is an experimental design where the test participant is randomly assigned to 1 of 3 conditions (1 control, 1 treatment, 1 placebo). Each participant then completes 6 different measures ...
ssjjaca's user avatar
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Making sure I interpreted my rma.mv output correctly (metafor)

I'm looking at investigating whether a tag in a fish is retained within the body (or not) and the factors that are likely driving this effect as part of a metanalysis. This includes the size of the ...
mlaw's user avatar
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Multiple Meta-Regression of Proportions

I am conducting a multiple meta-regression of proportions and was hoping that I could get some help. Outcome variable is complications rates (logit transformed) and moderators are publication year and ...
seven.sabs's user avatar
2 votes
1 answer
137 views

Should a meta-analysis of group differences calculate Hedges’ G separately for each group, or calculate Hedges' G for the group difference?

I am reading a meta-analysis where the authors state the following. (I've redacted the active drug name, as my purpose is to understand not call anyone out.) The treatment response to placebo and [...
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Appropiate name for coefficients of meta-regression

I would like to report the slope coefficient of several meta-regressions with one predictor. I am wondering what the correct term for this coefficient is. Is it simply b1 or is it β?
g4cco's user avatar
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Why do the confindence intervals overlap when my p-value is significant in meta-regression? [duplicate]

I fitted a mixed effects meta-regression model with one dummy-coded predictor (USA vs. Europe). The output tells me that the predictor is significant. I then wanted to get the average estimated effect ...
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What's the difference between fisher's Z and reliability&sample size adjusted r?

I am performing a meta analysis on random-effects model and I came across studies that compute r+ (sample size-adjusted correlation) and rc (reliability-adjusted correlation), and also those that ...
helpjpls's user avatar
2 votes
1 answer
78 views

Is it possible to do meta-regression with GAMLSS?

I am about to conduct a meta-regression analysis to fit some age-related changes. Since the GAMLSS approach is highly suggested in the normal regression of such data, I want to apply GAMLSS to my ...
Jack Yang's user avatar
2 votes
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Errors-in-variables random effects meta-regression

I would like to perform an error-in-variables random effects (DerSimonian and Laird method) meta-regression, but I do not know how one goes about doing this. Does anyone have any advice on if this is ...
M BG's user avatar
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Weighting pharmacovigilance data in a meta-regression

I would like to run a meta-regression in which the independent variable is composed of weighted reported odds ratios (ie, the number of events for a particular medication side effect divided by total ...
M BG's user avatar
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1 vote
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When should I care about the hierarchical structure of a few included studies for a meta-analysis (multiple independent groups, same outcome)?

I plan to meta-analyze proportion data (i.e. compliance rates in %) from >150 studies. Most of the studies will be single-group designs, but there will also be a few eligible multiple group studies ...
pieuvre's user avatar
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1 vote
1 answer
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Meta-regression with Peto's odds ratio? / best approach for rare events in control arm

I am conducting a meta-analysis with a binary outcome in which there are only 2 events in the control arm (most studies have 0) and an event rate of ~7% in the treatment arm. I have 2 questions: Can ...
Lindsay's user avatar
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3 votes
0 answers
63 views

Why are $R^2$ values not available in mixed effects meta regressions

I'm currently conducting a meta-regression for my predictors from a meta-analysis of proportion. In calculating the mixed effects meta-regressions, I wanted to identify how much heterogeneity is ...
Yakubu's user avatar
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1 vote
0 answers
237 views

interpretation of moderation in meta analysis

I'm conducting a meta-analysis using package metafor in r and I want to test the possible moderation effect of 3 variables. Of the 3 variables, only one gives me a significant effect on the '...
Enrico 's user avatar
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Arm-based meta-analysis of variation and mean with interval scale data

I’ve been extracting data for an arm-based meta-analysis on the distribution of a self-report survey in various research contexts. I am interested in the approach taken in Nagakawa et al. (2015), ...
thisisaname's user avatar
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How to find the optimal coefficients of the two predict_proba output matrices of two different classifiers using regression and maximizing accuracy? [closed]

I am performing classification, where there are six labels and two predict_proba (predicted probabilities) matrices as outputs. These two predict_proba matrices correspond to the outputs of two ...
cemrifki's user avatar
1 vote
0 answers
36 views

Meta-regression for continuous data - effect size or otherwise?

I'm trying to parse the output of multiple studies to quantify how age impacts the prevalence of HPV in Europe. Thanks to an excellent suggestion in a previous question, it has been suggested that ...
DRG's user avatar
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0 answers
125 views

How to compare ANOVA results from multiple data sets

I am trying to find out if there is an age-education category difference between people in the number of votes which they use while voting with a multiple vote voting method. Basically, I am trying to ...
Stefan A. Schulte's user avatar
3 votes
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124 views

Why are GLMMs distinct from GLMs for Meta-analysis of study level data?

Would anyone be able to explain conceptually why GLMMs with a random intercept at the study level are occasionally used for meta-analysis of proportions / counts, when the observations are already at ...
Richard Walker's user avatar
1 vote
0 answers
32 views

Meta regresssion with Standardized Mean Difference

I am doing a meta-analysis of studies comparing A and B. As some studies used different scales (measurement techniques), we have decided to pool all studies and used standardized mean difference (SMD)....
Kristanto Paulus's user avatar
1 vote
0 answers
68 views

Should I expect lower R2 with meta-regression in meta-analyses with low heterogeneity?

The question in short: Should I expect lower R2 values in meta-regression performed in a meta-analysis with low levels of heterogeneity? In meta-analysis, I2 represents a ratio of between-study ...
Clueless's user avatar
1 vote
0 answers
27 views

How can I validate my curve fitting meta-regression?

I'm doing a meta-regression analysis on Normal Pressure Hydrocephalus Gait Analysis. Studying the variation of gait velocity after a procedure (Tap-test). Keeping into account single study (#14) ...
Massimiliano 's user avatar
3 votes
0 answers
85 views

Considering sample size as controlling factor in meta-regression

In a meta-regression, authors have 3 explanatory variables of interest for 2 countries. But all these three variables were not present in all those studies which were finally selected for meta-...
time's user avatar
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2 votes
0 answers
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Predicted treatment effect for causally related conditions

Let's say there are two medical conditions $A$ and $B$ that are causally-related, i.e. that they share a common etiological process $C$. For example, $A$ and $B$ could be related autoimmune conditions ...
Brandon Brown's user avatar
1 vote
1 answer
408 views

How to back-transform regression coefficients in a multi-level meta-regression in metafor

My question is an extension of this one, where I asked about back-transforming the results of a reliability generalization meta-analysis. I have run a three-level meta-regression, using the Bonett-...
PyjamaNinja's user avatar
1 vote
0 answers
30 views

A reasonable choice of effect size for a meta-analysis

I'm doing a meta-analysis where the studies ask the study participants to read, find, and correct the wrong words in a text. Some studies score each study participant's performance on the text using: ...
Luke Martinez's user avatar
3 votes
1 answer
167 views

comparing effect sizes (partial correlations) for multiple outcomes in a meta-analysis

I'm conducting a meta-analysis using the metafor package. I'm using partial correlations and I'm interested in two effects - correlations between X and Y1 and X and Y2 (both controlling for Z). I have ...
llbia's user avatar
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1 vote
0 answers
113 views

Specifying a complex random-effects structure in metafor

I am working on a project in which I am using metafor to carry out a single-paper meta-analysis. My project contains data from 5 different studies; each study ...
Andrew V's user avatar
1 vote
0 answers
144 views

Combining moderator variables in meta-regression

I have a meta-analysis type dataset of compiled information from primary studies; including hazard ratio's and confidence intervals together with predictors (i.e. "moderators" in the context ...
user167591's user avatar
2 votes
1 answer
135 views

How to test for contrasts and interpret multiple meta-regression in metafor

Lets say I was meta-analysing studies which have assessed the influence of a warm- up on running performance (completely hypothetical). Lets also say that I wanted to find out whether pre-exercise ...
Cheddar_Thought's user avatar
2 votes
0 answers
100 views

Meta-regression analysis of the correlation between dependent variables

I have a set of studies which report a biomarker and an incidence of an outcome at baseline and at end of follow-up. I would like to get a measure of how much the change in the biomarker(chg_bm) ...
JensT's user avatar
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1 vote
0 answers
39 views

Could a nomogram be built from meta-regression coefficients?

I'm trying to build a nomogram from meta-regression co-efficients. The meta-regression model is done using the metafor package. However, I would like to represent the results into a nomogram. The RMS ...
Alan's user avatar
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4 votes
1 answer
158 views

Why are $R^2$ values not available in fixed effects meta regressions

I'm currently conducting a meta-regression for my moderators from a meta-analysis my team recently conducted. In calculating the fixed effects meta-regressions, my objective is to identify how much ...
r_user's user avatar
  • 337
6 votes
1 answer
364 views

What is the best way to regress proportions (as both dependent and independent variables)?

I am currently conducting a meta-analysis and have pooled the prevalence of a certain disease. I would like to check for any association of risk factors, such as gender, ethnicity, and disease ...
Aaron Mai's user avatar
2 votes
0 answers
85 views

Can I use logit transformed proportion as a independent variable for meta regression, while my dependent variable is also logit transformed?

I am now conducting a meta-analysis for depression in a certain disease. The prevalence of depression is available for the studies (n=21), and I would like to conduct meta regression with the ...
Aaron Mai's user avatar

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