Questions tagged [network-meta-analysis]
Network meta-analysis and mixed treatment comparisons are statistical techniques to synthesize evidence based on various comparisons, some of which may be only indirect.
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Why is there a discrepancy between the underlying meaning of variance between basic statistics and meta-analyses?
Normally, I would say that variance (and, in extension, standard deviation since it's just the square root of the variance) refers to a measure of deviation that describes how data points within a ...
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1answer
29 views
Is there a method/package that combines multivariate and network meta-analysis?
If you want to perform a meta-analysis on the general strength of the population and where each study can offer multiple outcomes (for example, measuring strength through deadlift capability and/or ...
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A reasonable choice of effect size for a meta-analysis
I'm doing a meta-analysis where the studies ask the study participants to read, find, and correct the wrong words in a text.
Some studies score each study participant's performance on the text using:
...
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1answer
31 views
Network Meta-analysis with poisson regression
I recently got interested in evidence sinthesis and, while studying, a little doubt came up to my mind:
Is it possible to do Network Meta-analysis using poisson regressions?
Also, is it possible to ...
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Network meta-analysis with trials of different follow-up time [closed]
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I am trying to do a network meta-analysis, and calculating anticipated absolute differences, I have seen other papers generating anticipated absolute differences for treatment for x number of years. ...
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How does tau squared (between-study variance) differ for network meta-analysis versus pairwise meta-analysis?
I'm currently trying to replicate a random effects network meta-analysis in Excel.
When estimating between-study heterogeneity, I can calculate Cochran's Q just fine via:
$$Q=\sum w_i(y_i-\hat\theta)^...
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1answer
116 views
Network-Meta Analysis of Observational Studies
Does anyone have experience on conducting a network-meta analysis based on observational studies?
Although network meta-analysis were proposed as a method to produce indirect comparisons between two ...
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0answers
28 views
Minimum Sample Size for a Two Stage IPD Meta-Analysis
I am attempting to run a IPD meta-analysis and I have 12 total studies with sample sizes ranging from 3 to 40 and was wondering is there is a minimum number to conduct a two-stage IPD, specifically as ...
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Meta analysis Model
I'm working on meta-analysis in the agricultural sciences.
I am looking for feedback on the rma.mv structure below for a multi-level model in metafor.
The data are structured such that: each group (4 ...
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1answer
47 views
A=B, A=C, B>C: Is this a violation of transitivity in a network meta-analysis?
If the results from a network meta-analysis using standard means differences (Hedges g) and using both direct and indirect evidence finds that:
Treatment A is not significantly less/more effective ...
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1answer
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Network Meta-Analysis: Do all included studies influence all ESs?
I am reviewing a NMA of over 10 interventions with wait-list control (WLC) groups being chosen as the reference group by the authors. I have done some reading and watched some videos on NMA and was ...
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How to conduct one-step IPD network meta-analysis?
I am new to meta-analysis... might be a newbie question but I'm wondering if the principles of conducting a one-step network meta-analysis are the same as doing it pairwise? (assuming that patients ...
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How to evaluating inconsistency and heterogeneity in a frequentist Network meta-analysis based exclusively on multi-armed studies?
I have been trying to perform a network meta-analysis on a set of 5 multi-armed trials, each having 3 arms (placebo, treatment 1, and treatment 2). I am using the network and network graphs packages ...
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30 views
Best meta-analytic approach with Mean, SD, Sample size for regional values of MRI measure
I'm interested in evaluting the evidence in the literature I've collected for spatial/anatomical variation in an MRI measure. The data consists of mean values, standard deviations and sample sizes, ...
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1answer
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Meta-analysis for complex data with many treatments (and often no controls)?
I'm planning to conduct a meta-analysis of the catches of invertebrates from various types of sampling methods - with the question of: 'which method catches the most inverts?'
In a preliminary ...
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1answer
134 views
Is it possible to have exactly identical output of random effects and fixed effect models in a network meta-analysis?
I conducted a network meta-analysis in frequentist framework using the R package netmeta (https://cran.r-project.org/web/packages/netmeta/netmeta.pdf), statistical details of this package are ...
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Are there extensions of publication-bias tests for Network Meta-Analysis?
In pairwise meta-analysis, it is common to check for publication bias. In particular, there are multiple tests for funnel-plot asymmetry (see here for Cochrane's recommendations about that: https://...
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1answer
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Reference request: initializing big neural networks with small neural networks
I am currently trying some meta-algorithms on training neural networks. Start with a small but expressive enough network for training and after several epochs, initialize a larger neural network with ...
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0answers
32 views
Comparing meta-analyses with partially overlapping controls
I would like to compare to meta-analyses that have semi-overlapping controls. In this situation, a single meta-analysis cannot be performed. There are known methods for comparing metas of ...
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1answer
62 views
INDIRECT COMPARISONS
I am conducting a project where I comparing a 5 different drugs (anti-psychotics) for a particular treatment group. There are currently no head-to-head trials for me to be able to make direct ...
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2answers
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Network meta-analysis of correlation coefficients: a logical paradox?
A colleague of mine wishes to conduct a network meta-analysis of correlation coefficients for a set of imaging tests (eg ultrasound, computed tomography, magnetic resonance imaging, and so forth).
...
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0answers
488 views
How to perform single-arm meta-analysis
I'm currently intending to perform a single-arm meta-analysis which study outcomes are: Objective Response Rate (ORR%), Disease Control Rate (DCR%), Duration of Response (DOR) in months, PFS in months,...
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1answer
119 views
Network meta analysis without standard deviations
I am trying to compute Cohen's in some studies that I gathered in a Systematic Literature Review.
Unfortunately, almost none of them report the standard deviation (nor df/t, or something for back-...
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326 views
What is the minimum number of studies needed to perform a network meta-analysis?
I have 5 studies each with a range of treatments - some of which do not overlap with other studies. So, for example:
Study 1: tx 1
tx 2
Study 2: tx 1
tx 3
Study 3: tx 1
...
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0answers
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Input data for network metanalysis using correlation coefficients.
1) Can you perform network meta-analysis with correlation coefficients?
2) if so, would the contrasts (for the r package netmeta) be the difference between one correlation and the other (simple ...
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1answer
64 views
Simultaneous network meta-analysis for multiple treatments and outcomes
I am interested in conducting a network meta-analysis (ie mixed treatment comparison) simultaneously pooling effect estimates for multiple treatments and outcomes, within the framework of an umbrella ...
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1answer
275 views
Network meta-analysis of diagnostic test accuracy studies
I need to make a network meta-analysis of diagnostic studies.
Is there a good explanation to do it with R?
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1answer
127 views
P value out of pairwise random effects network meta analysis
I am currently writing a meta-analysis using a pairwise random effects meta-analysis to compare the complication rates of 5 treatment modalities, with one as the gold standard. I was able to get RR's ...
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0answers
174 views
How can I impute the standard deviation for mean difference from p value?
I am doing meta-analysis comparing two groups. I came across a paper that provided the pre and post means with the standard deviation for three groups without providing the mean difference and its SD ...
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2answers
687 views
Network Meta-Analysis: Single Arm vs Contrasts Strategy Pros and Cons
I am working on a Network Meta-analysis that is aimed at comparing different treatments (medical vs surgery vs percutaneous approach) on short as well as long-term outcomes (including cardiovascular ...
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1answer
137 views
Meta-analysis data from studies comparing the “ecological” effect of a policy when some communities are shared by different studies?
I already made this question before (Is it appropriate to perform a meta-analysis of comparisons involving several communities where one of the communities was part of multiple studies?). I am making ...
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0answers
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Network meta-analysis - Why is confidence interval changed relative to pairwise comparison when only direct evidence exists?
I have a basic question about network meta-analysis (NMA). If a comparison between nodes is based completely on direct evidence with no indirect evidence, does that mean that no other interventions ...
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1answer
261 views
Is there a frequentist approach to Lu & Ades network meta-analysis model?
I'm currently reading the seminal Lu & Ades network meta-analysis paper. It proposes a bayesian hierachical model for dichotomous outcomes which treats each study's arm as an (conditionally) ...
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Which is the best method for network meta-regression?
Network meta-analysis (i.e. mixed treatment comparison) is becoming more and more important in evidence synthesis. An interesting aspect of this type of meta-analysis is the possibility to explore the ...
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1answer
1k views
Learning WinBUGS programming for network meta-analysis
I'm currently interested in learning NMA using WinBUGS. I studied the general concepts behind multiple treatment comparisons and i have a good base on classic pair-wise meta-analysis. I can also do a ...
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3answers
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Meta-analysis: splitting control group for multiple comparisons
I am conducting a meta-analysis in which some of the studies compare two or more interventions to the same control. The Cochrane Handbook recommends:
Combine groups to create a single pair-wise ...
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1answer
100 views
Meta-analysis of multiple diagnostic tests accuracies
I want to perform a meta-analysis of multiple diagnostic test at once. Outcomes are sensitivity, specificity, positive predictive value and negative predictive value. All the test have the same ...
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1answer
156 views
Is there any meaningfully robust approach to conduct a network meta-analysis of diagnostic test accuracy studies?
Background: I am working on a systematic review including several imaging modalities for coronary artery disease, but the evidence network is quite large, including different modalities, often ...
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2answers
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How to carry out adjusted indirect comparison or 'Bucher method' meta-analysis
I have carried out a pairwise meta-analysis of Drug 1 vs. placebo and a pairwise meta-analysis of Drug 2 vs. placebo (I have used RevMan software to do this). From each meta-analyses I have an overall ...
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1answer
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Which is the best method for network meta-analysis?
There are now several different approaches to perform a network meta-analysis or mixed treatment comparison.
The most commonly used and accessible ones are probably the following:
in a Bayesian ...
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1answer
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Main effects and interaction in multivariate meta-analysis (network meta-analysis) in R
I would like to conduct a multivariate meta-analysis (or network meta-analysis) to investigate the effect of two factors (A & B, 1 & 2). For every combination of the two factors I have a ...
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4answers
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Using mvmeta to perform a network meta-analysis
A few months ago, I posted these two questions about practical considerations in collecting data for a network meta-analysis and the available R packages that can analyze such data. For those ...
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2answers
571 views
Practical data collection tips for performing a network meta analysis (mixed treatment comparisons)
As described previously in this post, I am currently working through issues with conducting a network meta analysis (also known as mixed treatment comparisons). For those unfamiliar with this method, ...
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1answer
754 views
R software implementation of combining mixed treatment comparisons and meta-regression
I am currently conducting a meta-analysis in which I need to use a mixed treatment comparison method. As I understand it, this method works in the following way:
Say you have a group of studies that ...
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1answer
186 views
Multilevel Meta-analysis with several treatments
I have data on a number of studies comparing response rates to various treatments of a disorder. There are six different treatments, and some studies only test a single treatment. For each treatment ...
