Questions tagged [non-inferiority]

A non-inferiority study is designed to test whether one treatment is not worse than another.

Filter by
Sorted by
Tagged with
0
votes
0answers
10 views

Non-inferiority testing for two predictors using two non-nested logistic regression models

I have two continuous predictors that predict a binary outcome. One can be easily obtained while the other, the current standard, needs more work. I wish to prove that the new predictor is not ...
1
vote
0answers
30 views

help determining ROPE for bayesian multilevel probit model

I am having difficulty determining a justifiable region of practical equivalence (ROPE) for a parameter from a multilevel probit model Below is the posterior distribution for the fixed-effect of ...
0
votes
0answers
9 views

Sample size for non-inferiority test with low conversion rate

I am trying out a non-inferiority test for the first time. The baseline conversion rate is 0.75%. I want to test if the test variant is either better or at least the same as my current variant. How ...
0
votes
0answers
12 views

two sample t-test for placebo adjusted values

I have a set of studies (ex: s1....s6) in which each has two arms, a treatment and a placebo. I would like to test for non-inferiority through a matrix of two-sample t-tests w/o accounting for ...
0
votes
1answer
41 views

Power analysis for non-inferiority study

I'm doing a power analysis for a non-inferiority study based on this calculation from "Sample size calculations in clinical research" by Chow, Shao, Wang, and Lokhnygina: $$ n = \frac{(z_{\alpha}+z_{\...
1
vote
1answer
59 views

Non-inferiority margin and minimum detectable effect vs sample size

I am trying to understand why testing for non-inferiority requires pretty much the same sample size as testing for superiority (I assume the latter is the same as a one-sided test for a given MDE). I ...
3
votes
0answers
32 views

Is there a less arbitrary way define the margin in non-inferiority and/or equivalence trials?

In a typical equivalence trial, the researcher defines some threshold below which the difference between two means is not considered practically meaningful. In a non-inferiority trial, the same kind ...
0
votes
0answers
37 views

Noninferiority in a multilevel model

I am working on a randomized trial in which patients were randomized to one of two groups and followed over time, they were assessed at 5 time points including baseline. The outcomes include ...
1
vote
0answers
129 views

Sample size estimation for superiority/non-inferiority study

I am trying to estimate sample size for a superiority/non-inferiority study between two diagnostic tests. I have the AUCs of Model0 (standard test) and Model1 (new test), and other required parameters....
1
vote
0answers
162 views

Sample size calculation for 3 arm study “non-inferiority design” and continuous endpoints

I need to do a sample size calculation for a 3 arm study. Something like mentioned HIER! The endpoint is a severity score. The score can take integer values from 0 to 100 points. (i would consider ...
2
votes
1answer
77 views

Inconclusive results in non-inferiority design

I am interested in how an inconclusive result occurs given the formal null and alternative hypotheses required for non-inferiority testing. I have pre-specified a noninferiority design comparing ...
1
vote
0answers
483 views

How to perform multiple noninferiority tests with linear mixed models?

I want to test a theory that predicts that certain measures are greater than or equal than others. Consequently, I want to perform noninferiority tests. Furthermore, I want to get rid of some ...
1
vote
1answer
291 views

Determining Non-Inferiority with a 95% Confidence Interval

I have a sample of 1000 observations, divided into 2 groups: treatment and control (500 in each group). Each observation is dichotomous: 1 if an event occurred (bad event), and 0 if no event occurred. ...
4
votes
1answer
77 views

Non-inferiority test and bootstrapping

Background: I am trying to show that my method is as good as or better than a previously published work in the field of Automatic Speech Recognition. Usually, in the literature people usually report ...
9
votes
2answers
404 views

Can we accept the null in noninferiority tests?

In a usual t-test of means, using the usual hypothesis testing methods, we either reject the null or fail to reject the null but we never accept the null. One reason for this is that if we got more ...
1
vote
1answer
60 views

Testing equivalence (mean stayed the same)

We have an app, where you post projects and we'll be running A/B test on new version of posting page. How do we ensure that the new version is not worse? We have 14 days of time to decide that. And ...
5
votes
1answer
338 views

Noninferiority Using Logistic Regression

From the paper Equivalence and Noninferiority Testing in Regression Models and Repeated-Measures Designs the following graphic is taken. I am interested in a non-inferiority test between two ...
6
votes
1answer
215 views

Determine if two distributions are the same

I develop GNU Parallel. For each release I would like to test whether the version I am about to release has a memory leak. I can measure the memory usage. Unfortunately the usage varies slightly ...
2
votes
1answer
56 views

Estimating non-inferiority sample size

I'm projecting the number of patients needed for a clinical trial. Specifically, I'm using this model (https://www.sealedenvelope.com/power/binary-noninferior), and setting the variables as: (1) alpha ...
5
votes
1answer
2k views

Does statistically insignificant difference of means imply equality of means?

Suppose I have sets A and B of normally distributed data so that: A: mean=250, SD=200, N=25 B: mean=248, SD=200, N=20 Clearly, there is no statistically ...
2
votes
0answers
86 views

How to use a meta-analysis to assess the equivalence of two different procedures?

I'm making a comparison of two surgical procedures, and I want to know how I can analyze the data I have for a meta-analysis. The overall surgical procedure is the same, but some authors choose to ...
1
vote
0answers
102 views

Non-inferiority testing without normal approximation

I am performing a non-inferiority test on two binomial trials. I want to determine if my test proportion, pT, is not worse than my control, pC, by more than an amount d. Assuming nT trials of my test ...
5
votes
2answers
13k views

One-sided Fisher's exact test and its complement

If a one-sided Fisher's exact test testing the null hypothesis that A is not superior to B has a p-value of 0.98, is it true that the Fisher's exact test p-value for the null hypothesis that B is not ...