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Questions tagged [number-needed-to-treat]

NNT is a common measure of effect size in the biomedical sciences. It is the number of patients that you expect to have to treat in order to cure one patient. Also use this tag for questions about the number needed to harm.

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How to calculate NNT when it's NOT a clinical trial?

I am working on a revise and resubmit for a journal article. This is an observational, cross-sectional study. We compared endorsements of different behaviors across groups (e.g., 30.1% of Group 1 ...
Blair Burnette's user avatar
1 vote
1 answer
181 views

Risk difference with patient-years incidence rates

I am aware that you can compute risk differences as the difference of risk between two treatment arms $( (\text{No. events}_1/ N_1) - (\text{No. events}_2 / N_2))$. However, can I estimate the same ...
Claudio Laudani's user avatar
1 vote
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Reporting significance values for relative risk (RR) and number needed to treat (NNT)

I have calculated the relative risk & number needed to treat using the log-binomial regression model. NNT is calculated as the reciprocal of the marginal difference. Does it make sense to report ...
Megan Moreton's user avatar
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How to incorporate the customers leaving (addition of new ones) in the measurement of treatment effectiveness?

Consider I have taken a random sample for forming control group in month of January with sample size 5k and treatment group size being 95k. I am Sending offers to treatment group which are intend to ...
Artiga's user avatar
  • 333
5 votes
1 answer
500 views

What are the problems with number needed to treat (or harm) in observational studies?

I have been asked to comment on the use of NNT (number needed to treat) and NNH (number needed to harm) in observational studies. My intuition doesn't give me any reasons these would be problematic ...
Peter Flom's user avatar
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1 vote
1 answer
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Absolute risk and NNT from logistic regression

I fitted a Logistic regression with a number of variables, and was asked about the absolute risk (AR) and number needed to treat (NNT) for one of the variable with the outcome. I understand how to ...
Inji's user avatar
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1 vote
1 answer
423 views

Deciding Optimal Cutoff for a Prognostic Index derived from Cox Proportional Hazards

I am planning to develop a prognostic model that would identify a particular group of head neck cancer patients who will do better if chemotherapy is added to standard radiation therapy. The data for ...
Santam's user avatar
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3 votes
1 answer
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Two methods to calculate the confidence interval for number needed to treat yield different results

Assume that two drugs were tested. The risk of death for drug 1 is $p_1$ and the risk for drug 2 is $p_2$. We define: Risk difference (RD) $RD=p_1-p_2$ The number needed to treat (NNT) $NNT=1/|RD|$ ...
fiona's user avatar
  • 31