Questions tagged [replicability]

The extent to which subsequent studies of the same phenomenon reproduce the results obtained in the original study.

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Repeating experiment with biological replicates

My experiment gives data of 12 biological replicates. This would be sufficient to calculate the mean and give a valid standard deviation. However, there might have been some pipetting errors that ...
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Two-Way ANOVA with significant interaction with replication, how to proceed?

Good morning everyone. I am performing an omnibus two-way anova test. In the set of factors that I want to test I included biological replication and technical replication. The function used for the ...
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Replicating a wrong analysis

A study measures the performance of patients and controls in two tasks. In task 1, a t-test reveals no significant differences between patients and controls. In task 2, a t-test reveals significant ...
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70 views

Does this analysis commit pseudoreplication?

I designed my experiment in a way that I thought would present me with options for analysis, but I'm starting to wonder if one of the options would be considered pseudoreplication. The experiment was ...
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Replication after Meta-Analysis in a multiple testing situation?

I was recently in an introductory seminar about Genome Wide Association Studies (GWAS). These studies aim to examine if any genetic markers are associate with a certain trait. It is not uncommon to ...
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728 views

Pooling data from replicate experiments 2

I have a problem regarding pooling data from replicate experiments. I have done an experiment where I collected multiple tissue samples from 5 mice, then the samples were allocated to treatments and ...
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24 views

Testing two groups of subjects (same population) -> increased replicability?

I've seen several experimental psychology papers arguing that, because they separately tested two cohorts of subjects, that this increases the replicability of their finding. Is this really the case? ...
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Difference between sample size and replicates

I am unsure of what is counted as separate samples, the size of a sample, and what is counted as a replicate, or if there is a distinction. The following is not a homework or assigned question, merely ...
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16 views

When to average technical replicates to get experimental replicate value?

I'm having trouble deciding when to average technical replicates from an experiment. The scenario is this: 4 Experimental replicates (i.e. experiments done on separate days) 3 Technical replicates ...
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39 views

Does `friedman.test()` need assumption of `balance design`?

I want to know whether friedman.test() need assumption of balance design. Then I searched R ...
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2answers
48 views

Within-sample p-value VS across-samples p-value for the same test statistic

I have a volume of brain which contains thousands of connections between hundreds of cells. Suppose I observe that Cell type A connects three times more to Cell type B than Cell type C, and calculate ...