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How are the null distributions created for hypothesis testing?

I'm struggling to connect the idea of a sampling distribution of a test statistic to the null distribution. If I run many simple linear regressions on samples extracted from a population of data I ...
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Generating variables using R

Question: Assume 2 treatments, 1 and 0. Given 120 participants, generate underlying truth with Age as a discrete uniform distribution over integers between [20-60] Gender (G) as $I\{G = F\} \sim \...
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Permutation of datasets to check accuracy of class labels

Currently I am using a proteomics dataset to compare 4 different disorders to healthy controls. Ultimately, I want to find unique and overlapping factors (that are deviant from healthy controls) in ...