Questions tagged [systematic-review]

The process of collecting already existing studies in a reproducible systematic way. If your question is about the statistical analysis of studies which have been collected in this way consider using the meta-analysis tag as well or instead.

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How to compare ANOVA results from multiple data sets

I am trying to find out if there is an age-education category difference between people in the number of votes which they use while voting with a multiple vote voting method. Basically, I am trying to ...
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Scientific meta analysis

I will be analysing the effects of enzyme inhibitors on a certain enzyme on invivo and invitro animal and human cancer cell model lines as this enzyme is associated with pathogenicity; to assess ...
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Should I use effect sizes from multiple regression or raw correlations for meta-analyses?

I am conducting a meta-analysis and have encountered a study that provides both correlation coefficient and multiple regression statistics for the same effect. Is using effect sizes from multiple ...
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Interpretation of analysis of post-intervention measurements when discarding change from baseline analysis

I am currently in the process of creating a systematic review. The review summarises the results of multiple study, which report a certain outcome measure (the distance some athletes can throw) for ...
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Meta-analysis - no control groups!

I am conducting a meta-analysis of volumetric growth rates of a specific tumour type, per year, after surgery. The studied included have no control groups, but rather arms of interventions. I am ...
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Analysing non-outcome variables in meta-analysis

I am working on a meta-analysis project in suicidology. This is more like an academic exercise and will not necessarily be submitted for publication, but I try to be as rigorous as possible. Now here ...
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Pooling in a Meta Analysis

I am looking to pool data for adverse events for a meta analysis and I wanted to see if my plan made sense I want to pool my AE together based on the Clavien Dindo categorizations, as this will make ...
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How to account for confounder in systematic reviews?

I am performing a systematic review of the literature and the data is stored as a table including the fields: DISEASE, VIRUS, TISSUE, ASSAY. I made a random effect model for each of the first three ...
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Converting zero count regression model back to frequency data?

I’m new to statistics but I’m performing a systematic review into exercise and alcohol intake. One of the papers uses a zero inflated count regression model to report the alcohol consumption per day. ...
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Best tool to appraise the internal validity of a systematic review or meta-analysis

We are conducting an evidence base synthesis for a major European cardiovascular assocation. We plan to search, appraise and summarize systematic reviews and meta-analyses on our topic of choice, ...
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Meta-analysis of time-to-event data for single group design

I would like to perform a meta-analysis of time-to-event data for a single group (i.e. there is no comparison group). How do I do so, what are the statistics required? I understand that for 2-group ...
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Comparing means and medians (with different dispersion indeces) from different studies

I'm doing a systematic search and I have a pool of articles that for each outcome report different central values (mean and median) and dispersion indices (SD, 95% CI, IQR). Is there a statistical ...
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How to assess agreement among measurement models (factor analysis) from multiple studies?

For a meta-analysis, I've been collating studies that apply factor analysis on likert-like scale surveys for a specific psychometric construct. The original speculation from source material is that ...
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how to estimate means and SD from clustered means in a study

for conduction of a meta-analysis I am collecting data from various studies. Unfortunately, not every author provides means for all groups, instead, means are clustered. Say, I have independent ...
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Should I be running a meta-analysis?

I am working on a project that assesses the slope of the species area curve across multiple studies (right now I have 35 studies). I have slope values for all these studies and all of these slopes ...
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2 votes
1 answer
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Fisher's method for combining p-values

I'm using the sumlog function in the metap package of R, and have a few questions about the nuts-and-bolts of this function: 1)Some of my p-values are reported as '<0.001'. How do I include these?...
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Meta-analysis with incomplete data

I'm doing a meta-analysis comparing infection rates in 2 sub-types of liver operations (say Big surgery Vs Small surgery). I have a few studies which compare the 2 but other studies that only report ...
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Meta-analysis with only p-values

I am doing a systematic review on the risk factors that predict infection after liver and pancreatic surgery. These risk factors include parameters like age, sex, smoking, pre-operative chemo etc. I ...
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Checking association between each category of a variable and disease outcome

Suppose a disease can have four different outcomes: Normal, disease_status_1, disease_status_2, and disease_status_3. Let I have two categorical variables in the model: sex (male or female) and age (&...
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Can one perform a meta analysis on solely the results of a study, without the use of raw data? [closed]

If not, since a systematic review would be the next option, are there any analyses you can conduct on the results of the studies that one intends to analyze
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1 vote
1 answer
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Problem in accuracy when calculating p value from a 95% confidence interval

For my meta-analysis I have to obtain univariate analyses (HR, 95% CI, p value) from different studies. I came across one study with a given HR: 1.19 and 95% CI: 0.46 - 2.51. By surfing on the ...
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Calculate Kappa inter-rater reliability score for two categories where one has multiple but equivalent options

I'll try to be clear by describing the data and the problem. This is for a systematic review of a specific research literature. All articles can be either 'included' or 'excluded'. However for the ...
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How to combine observational studies

I am trying to show the releationship between a drug and an outcome in a particular setting. Using a systematic review, I have found 18 studies addressing this topic. Among those, the highest quality ...
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1 answer
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Is it appropriate to pool incidence data from a systematic review for a summary RR?

I have a systematic review to compare incidence of an illness (Y) with or without an intervention (so groups A and B). These groups are relatively homogeneous, so aside from unmeasured confounders I ...
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1 answer
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Can I perform a meta analysis with my data?

I have 10 studies who look at a surgery for facial paralysis. The main outcome is time to nerve recovery. I have the mean, SDs for the time in months to recovery but obviously there is no control or ...
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1 answer
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Getting the Average (?) of data from literature review

I have reviewed many literature, and extracted their data. I wanted to get the average of the values of each property. Say, I have 50 journal articles which reported the metal composition (as % ...
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2 votes
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Comparing pooled complication rates

I have started a meta analysis comparing the complication rates of different treatments of distal radius fractures. I have pooled the complication rates (n/N) for each treatment separately using the ...
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1 answer
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Fields of application of meta-analysis

Systematic reviews and meta-analyses have been used extensively in many fields and for many years. For instance, there are exceedingly numerous examples of systematic reviews and meta-analyses in ...
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2 votes
1 answer
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Pool data for systematic review

I am new to this website and to statistics as well. Currently I am writing a systematic review on complications and reoperations after distal radius fractures(Systematic review on the comparison of ...
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How to calculate a new mean from different means for my Systematic Review and how to calculate a new SD?

I am currently doing a systematic review on distal radius fractures. I want to give a mean age and sd in my systematic review. Therefor I need to calculate the mean from all the different means of the ...
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1 vote
1 answer
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Standardizing odds ratios with opposite outcomes for lit review

When doing a lit review, I find that results are frequently presented in different ways. Sometimes the outcome is Facility Births (FB), sometimes it is Home Births (HB). These are dichotomous outcomes....
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3 votes
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Which is the best method for network meta-regression?

Network meta-analysis (i.e. mixed treatment comparison) is becoming more and more important in evidence synthesis. An interesting aspect of this type of meta-analysis is the possibility to explore the ...
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1 answer
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How to perform a meta regression in SPSS or R? [closed]

I am working on a systematic review looking at the global prevalence of pain, I am trying to do a meta regression to examine what effect gender, age, etc has on the prevalence of pain. I have no prior ...
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8 votes
1 answer
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Is there any meaningfully robust approach to conduct a network meta-analysis of diagnostic test accuracy studies?

Background: I am working on a systematic review including several imaging modalities for coronary artery disease, but the evidence network is quite large, including different modalities, often ...
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