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Roland
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Meta-analysis of ROC areas missing confidence interval

I am performing a meta-analysis of a diagnostic score going from 0 to 10 based on 30 reports. For each report I have data on number of false/true positive/negative patients for one and in some cases two cutoff points (low and high). I plan to do meta analysis on sensitivity and specificity for these results.

For most reports I also have information on the ROC area of the complete score but for most reports I miss the confidence interval.

I can of course make ROC estimates from the cutoff points but would prefer using the ROC area that is provided from the complete score. Can I use the reported ROC areas and the total number of patients for each report as weights to pool the ROC areas?

Roland
  • 301
  • 1
  • 6