Here's an example in Stata of how to create the ratio and test a hypothesis using `nlcom`: . webuse regress . regress y x1 x2 x3 Source | SS df MS Number of obs = 148 -------------+------------------------------ F( 3, 144) = 96.12 Model | 3259.3561 3 1086.45203 Prob > F = 0.0000 Residual | 1627.56282 144 11.3025196 R-squared = 0.6670 -------------+------------------------------ Adj R-squared = 0.6600 Total | 4886.91892 147 33.2443464 Root MSE = 3.3619 ------------------------------------------------------------------------------ y | Coef. Std. Err. t P>|t| [95% Conf. Interval] -------------+---------------------------------------------------------------- x1 | 1.457113 1.07461 1.36 0.177 -.666934 3.581161 x2 | 2.221682 .8610358 2.58 0.011 .5197797 3.923583 x3 | -.006139 .0005543 -11.08 0.000 -.0072345 -.0050435 _cons | 36.10135 4.382693 8.24 0.000 27.43863 44.76407 ------------------------------------------------------------------------------ . nlcom ratio:_b[x1]/_b[x2], post ratio: _b[x1]/_b[x2] ------------------------------------------------------------------------------ y | Coef. Std. Err. t P>|t| [95% Conf. Interval] -------------+---------------------------------------------------------------- ratio | .6558606 .4221027 1.55 0.122 -.1784571 1.490178 ------------------------------------------------------------------------------ . test ratio=.5 ( 1) ratio = .5 F( 1, 144) = 0.14 Prob > F = 0.7125 There are formulas in the pdf manual under `nlcom`. A terse explanation can be found in [the Stata FAQ on the delta method][1]. ---------- **Added in response to the OP's comment below:** If you have two separate regressions, you have all the ingredients for the formula that Glen_b linked to, other than the covariance term. You can assume it's zero if that makes sense with your model, or you can estimate the two equations as a system, which will give you cross-equation covariances between the coefficients. It's hard to know which is better without the details. One way (out of several possible ways) to do the latter is with [Seemingly Unrelated Regression][2]: . webuse regress . sureg (eq1:y x1 x2) (eq2:y x1 x3) Seemingly unrelated regression ---------------------------------------------------------------------- Equation Obs Parms RMSE "R-sq" chi2 P ---------------------------------------------------------------------- eq1 148 2 4.54006 0.3758 91.48 0.0000 eq2 148 2 3.770546 0.5694 211.94 0.0000 ---------------------------------------------------------------------- ------------------------------------------------------------------------------ | Coef. Std. Err. z P>|z| [95% Conf. Interval] -------------+---------------------------------------------------------------- eq1 | x1 | 7.472932 .98949 7.55 0.000 5.533568 9.412297 x2 | -.4768772 .7799875 -0.61 0.541 -2.005625 1.05187 _cons | -1.374358 2.883296 -0.48 0.634 -7.025514 4.276798 -------------+---------------------------------------------------------------- eq2 | x1 | 4.338581 .7852935 5.52 0.000 2.799434 5.877728 x3 | -.0026865 .0003774 -7.12 0.000 -.0034261 -.0019468 _cons | 16.32873 3.214735 5.08 0.000 10.02797 22.6295 ------------------------------------------------------------------------------ . nlcom ratio:[eq1]_b[x1]/[eq2]_b[x1] ratio: [eq1]_b[x1]/[eq2]_b[x1] ------------------------------------------------------------------------------ | Coef. Std. Err. z P>|z| [95% Conf. Interval] -------------+---------------------------------------------------------------- ratio | 1.722437 .2773696 6.21 0.000 1.178803 2.266071 ------------------------------------------------------------------------------ [1]: http://www.stata.com/support/faqs/statistics/delta-method/ [2]: http://www.ats.ucla.edu/stat/stata/faq/sureg.htm