Tibshirani introduced once a more general type of Lasso, where the regularizer is $$\parallel D \alpha \parallel_1$$ instead of $\parallel \alpha \parallel_1$. https://www.google.de/url?sa=t&source=web&cd=3&ved=0CD8QFjAC&url=http%3A%2F%2Fwww.stat.cmu.edu%2F~ryantibs%2Fpapers%2Fgenlasso.pdf&ei=-eBgUrb2JsXJtQbNt4G4DA&usg=AFQjCNEkozLb8jphoTMP8weGoy-8cVeDVw&sig2=-RbeTlE-S-UXTC1Mcce6zQ However, there is nearly no discussion about this form and I wonder why since its a great way to deal with derivative smoothness regularizers. - Is there an easy way I overlooked to transform a general Lasso to the standard Lasso form? Thank you!