While helping someone else with their analyses, I've run into a question regarding the difference between t-tests and F-tests for linear mixed models in lme4 for R, as provided by lmerMod. I'm aware of the problems with calculating any kind of p-values for linear mixed models (as I understand, primarily due to the fact that definition of the degrees of freedom is problematic), as well as the problems with interpreting main effects in the presence of significant interactions (based on the marginality principle).

Briefly, the data are from an experiment with two conditions (congruity TRUE/FALSE), measured on six sets of sensors which can be described as a combination of two factors: anteriority (anterior/posterior) and laterality (left/central/right).

As can be seen from the summary output below, the t.tests do not show a significant congruity effect (p = 0.12), while the anova output shows a very significant congruity effect (p = 2.8e-10). Since congruity has only two levels, this cannot be the result of the F-test doing an omnibus test over several levels of the fixed factor. I am therefore unsure what causes the very significant result in the anova output. Is this due to the fact that there are strong interactions involving congruity which of course depend on the inclusion of the main effect in the model parametrization?

I have looked for a previous answer to this question on CrossValidated but I have not been able to find anything relevant except possibly [the first answer to this question][1]. However, if that does provide a real answer then it is implicit in the mathematics, and I am looking for a conceptual answer that I can explain to the person I am trying to help.

    > final.mod<-lmer(uV~1+factor(congruity)*factor(laterality)*factor(anteriority)+(1|sent.id)+(1|Subject),data=selected.data)
    > summary(final.mod)
    Linear mixed model fit by REML 
    
    t-tests use  Satterthwaite approximations to degrees of freedom ['lmerMod']
    Formula: uV ~ 1 + factor(congruity) * factor(laterality) * factor(anteriority) +      (1 | sent.id) + (1 | Subject)
       Data: selected.data
    REML criterion at convergence: 348903.5
    Scaled residuals: 
    Min      1Q  Median      3Q     Max 
    -7.0440 -0.6002  0.0069  0.6038 11.3912 
    Random effects:
     Groups   Name        Variance Std.Dev.
     sent.id  (Intercept)   1.773   1.332  
     Subject  (Intercept)   2.548   1.596  
     Residual             111.396  10.554  
    Number of obs: 46176, groups:  sent.id, 41; Subject, 30
    Fixed effects:
                                                                         Estimate Std. Error         df t value Pr(>|t|)  
    (Intercept)                                                                 4.768e-03  3.973e-01  7.900e+01   0.012   0.9905  
    factor(congruity)TRUE                                                       3.758e-01  2.410e-01  4.611e+04   1.559   0.1189  
    factor(laterality)left                                                      7.154e-02  2.430e-01  4.610e+04   0.294   0.7685  
    factor(laterality)right                                                    -2.003e-01  2.430e-01  4.610e+04  -0.824   0.4098  
    factor(anteriority)posterior                                               -4.203e-02  2.430e-01  4.610e+04  -0.173   0.8627
    factor(congruity)TRUE:factor(laterality)left                               -1.013e-01  3.404e-01  4.610e+04  -0.298   0.7660
    factor(congruity)TRUE:factor(laterality)right                               7.233e-02  3.404e-01  4.610e+04   0.213   0.8317
    factor(congruity)TRUE:factor(anteriority)posterior                          6.162e-01  3.404e-01  4.610e+04   1.810   0.0702 .
    factor(laterality)left:factor(anteriority)posterior                         2.568e-01  3.437e-01  4.610e+04   0.747   0.4549
    factor(laterality)right:factor(anteriority)posterior                        1.763e-01  3.437e-01  4.610e+04   0.513   0.6080
    factor(congruity)TRUE:factor(laterality)left:factor(anteriority)posterior  -5.162e-02  4.813e-01  4.610e+04  -0.107   0.9146
    factor(congruity)TRUE:factor(laterality)right:factor(anteriority)posterior -2.420e-01  4.813e-01  4.610e+04  -0.503   0.6152  
    ---
    Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
    Correlation of Fixed Effects:
                              (Intr) fc()TRUE fctr(ltrlty)l fctr(ltrlty)r fctr(n) fctr(cngrty)TRUE:fctr(ltrlty)l fctr(cngrty)TRUE:fctr(ltrlty)r
    fctr(c)TRUE                       -0.310
    fctr(ltrlty)l                     -0.306  0.504
    fctr(ltrlty)r                     -0.306  0.504    0.500
    fctr(ntrrt)                       -0.306  0.504    0.500         0.500
    fctr(cngrty)TRUE:fctr(ltrlty)l     0.218 -0.706   -0.714        -0.357        -0.357
    fctr(cngrty)TRUE:fctr(ltrlty)r     0.218 -0.706   -0.357        -0.714        -0.357   0.500
    fctr(cngrty)TRUE:fctr(n)           0.218 -0.706   -0.357        -0.357        -0.714   0.500                          0.500
    fctr(ltrlty)l:()                   0.216 -0.357   -0.707        -0.354        -0.707   0.505                          0.252
    fctr(ltrlty)r:()                   0.216 -0.357   -0.354        -0.707        -0.707   0.252                          0.505
    fctr(cngrty)TRUE:fctr(ltrlty)l:() -0.154  0.499    0.505         0.252         0.505  -0.707                         -0.354
    fctr(cngrty)TRUE:fctr(ltrlty)r:() -0.154  0.499    0.252         0.505         0.505  -0.354                         -0.707                        
                              fctr(cngrty)TRUE:fctr(n) fctr(ltrlty)l:() fctr(ltrlty)r:() fctr(cngrty)TRUE:fctr(ltrlty)l:()
    fctr(c)TRUE
    fctr(ltrlty)l
    fctr(ltrlty)r
    fctr(ntrrt)
    fctr(cngrty)TRUE:fctr(ltrlty)l
    fctr(cngrty)TRUE:fctr(ltrlty)r
    fctr(cngrty)TRUE:fctr(n)
    fctr(ltrlty)l:()                   0.505
    fctr(ltrlty)r:()                   0.505                    0.500
    fctr(cngrty)TRUE:fctr(ltrlty)l:() -0.707                   -0.714           -0.357                                            
    fctr(cngrty)TRUE:fctr(ltrlty)r:() -0.707                   -0.357           -0.714            0.500                           
    > anova(final.mod)
    Analysis of Variance Table of type III  with  Satterthwaite 
    approximation for degrees of freedom
                                                     Sum Sq Mean Sq NumDF DenDF F.value    Pr(>F)    
    factor(congruity)                                        4439.1  4439.1     1 46142  39.850 2.768e-10 ***
    factor(laterality)                                        572.9   286.5     2 46095   2.572  0.076430 .  
    factor(anteriority)                                      1508.1  1508.1     1 46095  13.538  0.000234 ***
    factor(congruity):factor(laterality)                       31.6    15.8     2 46095   0.142  0.867581    
    factor(congruity):factor(anteriority)                     775.1   775.1     1 46095   6.958  0.008349 ** 
    factor(laterality):factor(anteriority)                    111.9    56.0     2 46095   0.502  0.605126  
    factor(congruity):factor(laterality):factor(anteriority)   31.2    15.6     2 46095   0.140  0.869183    
    ---
    Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1


  [1]: https://stats.stackexchange.com/questions/16947/difference-between-t-test-and-anova-in-linear-regression "this"