Timeline for Statistical test for multiple comparison of groups of animals with Yes or No outcome
Current License: CC BY-SA 3.0
8 events
| when toggle format | what | by | license | comment | |
|---|---|---|---|---|---|
| Feb 9, 2015 at 11:50 | vote | accept | R.P. Tamil Selvan | ||
| Jan 7, 2015 at 22:08 | answer | added | EdM | timeline score: 1 | |
| Jan 7, 2015 at 5:34 | comment | added | R.P. Tamil Selvan | yes i agree with titer over 12 monthis also a indicator for vaccine efficacy. However, requirement by regulatory bodies is by challenge of animals. the result indicates yes/no each animal. so the correlation need to be calculated for protection and antibody titer versus each vaccine type, which is my 4th research question. moreover preclinical stuides are aimed to screen for best vaccine compared to one standard vaccine group(T-02&T-03) and absolute control (T-01) and are thats why carried out with 8 animals in each group. Work was desined with statisticians help. now i don't have that help. | |
| Jan 3, 2015 at 18:39 | comment | added | EdM | The small number of animals in each group may make it difficult to find which vaccine is best if you use yes/no responses. Even if 8/8 are protected in a particular sample, the Clopper-Pearson 95% CI goes down to a fraction as low as 0.63 protected in the population; 95% CI based on 2/8 protected in a sample goes as high as a fraction of 0.65 protected. (See statpages.org/confint.html .) So it will be hard to distinguish among vaccines this way. A continuous measure like titer, perhaps integrated over the 12 months, might do better. | |
| Jan 3, 2015 at 15:39 | history | edited | gung - Reinstate Monica | CC BY-SA 3.0 |
edited tags; edited for English; formatted; removed irrelevant comments
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| Jan 3, 2015 at 14:44 | review | Close votes | |||
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| Jan 3, 2015 at 7:55 | review | First posts | |||
| Jan 3, 2015 at 8:06 | |||||
| Jan 3, 2015 at 7:51 | history | asked | R.P. Tamil Selvan | CC BY-SA 3.0 |