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Dec 2, 2016 at 21:26 answer added Ruben van Bergen timeline score: 4
Dec 2, 2016 at 19:44 comment added EdM This Cross Validated page also addresses the inability of bootstrapping to overcome small sample sizes; its advantage is not needing to make assumptions about distributions. Permutation tests might be more useful in some circumstances.
Dec 2, 2016 at 18:57 comment added EdM Could you say a bit more about specifics of your study: how many samples, numbers of experimental treatments, numbers of metabolites measured, and so on? Those details can make a difference.
Dec 2, 2016 at 18:35 answer added bdeonovic timeline score: 6
Dec 2, 2016 at 18:00 comment added Frank Fan @Repmat Thanks for quick response. I added some more context from the reviewer.
Dec 2, 2016 at 18:00 history edited Frank Fan CC BY-SA 3.0
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Dec 2, 2016 at 17:56 comment added Repmat Actually there about as many variations on the bootstrap as you can possible imagine... Typically you bootstrap the t statistic, and use the distribution instead of the theoretical t distribution. I would like to add that the bootstrapping itself does not save you from small sample problems, as the reviewer appears to think. Can you provide more context?
Dec 2, 2016 at 17:49 review First posts
Dec 2, 2016 at 18:18
Dec 2, 2016 at 17:48 history asked Frank Fan CC BY-SA 3.0