I have 3 factors factor1 (treatment) with 2 levels (control, stress) factor2 (Variates) with 12 Levels (Var1, Var2,....Var12) factor3 (Time) with 12 levels (Week1, Week2,..., Week12)

The treatment has 3 replicates for control and 6 replicates for stress. Would it be unbalanced Design? What design would you suggest in this case?

looking forward for your positive response! Thanks in advance! Regrads, Jacki