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Nov 7, 2022 at 1:22 comment added dipetkov Are measurements that were never taken by design (whether the experiment was well designed or not) a missing data problem? Also, LMMs don't expect the dataset is balanced; this is a full-likelihood method which models the data that was actually observed. This paper might be of interest: Multiple imputation of missing values was not necessary before performing a longitudinal mixed-model analysis.
Nov 5, 2022 at 19:04 history asked André Barros CC BY-SA 4.0