A covariance matrix $\mathbf C$ is called isotropic if it is proportionate to the identity matrix: $$\mathbf C = \lambda \mathbf I,$$ i.e. it is diagonal and all elements on the diagonal are equal.
This definition does not depend on the coordinate system; if we rotate coordinate system with an orthogonal rotation matrix $\mathbf V$, then the covariance matrix will transform into $$\mathbf V^\top \mathbf C \mathbf V = \mathbf V^\top \cdot \lambda \mathbf I \cdot\mathbf V = \mathbf V^\top \mathbf V \cdot \lambda \mathbf I = \lambda \mathbf I,$$ i.e. will stay the same.
Intuitively, isotropic covariance matrix corresponds to a "spherical" data cloud. A sphere remains a sphere after rotation.