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The accuracy of the cut-off is significantly dependent on an independent continuous variable

Say one continuous variable differentiates between disease and nondisease quite accurately, but as people progress in age, this variable becomes less accurate.

Is there a way to determine the accuracy of this variable on the continuous scale of age?

This is for example the case considering the BMI in predicting the cardio-metabolic health; an increased BMI is less reflective for the cardio-metabolic health as people progress in age.

I have no data at the current moment, but if strictly necessary according to the rules of the forum, I can try to simlate a dataset.