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stats134711
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Pooled logistic regression with irregular intervals

I'm planning an analysis that will require pooled logistic regression to analyze a longitudinal dataset with time-dependent explanatory variables (see here - D'Agostino, et al. 1990). However, the standard analysis uses regularly spaced intervals. My study has followup points at 0,2,6,12,24 months. What is a good way to model the effects of time given this structure of unevenly spaced intervals? Would a restricted cubic splines for the effects of time address the irregularity issue?

Thanks!

stats134711
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