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Statistical significance is a characteristic of a statistic viewed in light of a null hypothesis and a given significance level. It reflects whether the statistic belongs to the rejection region (is statistically significant) or the acceptance region (is not statistically significant).
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What is a good measure (or set of measures) for the difference between two sample sets?
what kind of output are you getting? are you using regression? if you're trying to measure which set is best to use, you can use an F test using the sample errors, but I'm not sure what exactly you're …