Timeline for Is it sound to use a regression model to identify excessive medication dosage for individual patients?
Current License: CC BY-SA 4.0
11 events
| when toggle format | what | by | license | comment | |
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| Feb 22, 2019 at 15:47 | comment | added | T. Shiftlet | Absolutely agreed on the Warfarin pharmacokinetrics. Warfarin was just an example! But yes, we are incorporating a variety of drug interactions and patient behavior. | |
| Feb 22, 2019 at 1:25 | comment | added | StatsStudent | +1,Excellent point, @EdM. This just highlights the importance of asking good questions! | |
| Feb 21, 2019 at 22:13 | comment | added | EdM | Warfarin pharmacokinetics are extremely complicated and doses are typically chosen by performing a clotting test such as INR, as doses are adjusted over time to get INR values into the correct range. Are you trying to model INR or warfarin levels? In any event, I trust that you are incorporating information about interacting drugs and dietary components that are known to be related to the clotting effect of administered warfarin. Omitting variables known to be related to INR or warfarin levels can be misleading or dangerous, even statistically. | |
| Feb 21, 2019 at 20:45 | vote | accept | T. Shiftlet | ||
| Feb 21, 2019 at 15:35 | comment | added | StatsStudent | So why not simply take average dosages of patients with the same demographics? That would be the expected value. You could then flag any patients with a dosage greater than this amount. It seems like you might be trying to use more statistical machinery and complexity than needed here. | |
| Feb 21, 2019 at 15:28 | comment | added | T. Shiftlet | We do know the dosage of all patients. - the goal is to determine when the patient is receiving a dosage higher than what is expected. | |
| Feb 21, 2019 at 15:11 | comment | added | StatsStudent | So you don't know the dosage of all patients? I'm not sure how any physician would not know the actual warfarin dosage. Can you help us understand why you are trying to predict warfin dosage as opposed to simply reading it from the patient's chart? Can you help us understand how the dosages are missing? | |
| Feb 21, 2019 at 15:05 | answer | added | Amr Tarek Elmzayen | timeline score: 2 | |
| Feb 21, 2019 at 15:02 | answer | added | David | timeline score: 0 | |
| Feb 21, 2019 at 14:45 | review | First posts | |||
| Feb 21, 2019 at 15:21 | |||||
| Feb 21, 2019 at 14:44 | history | asked | T. Shiftlet | CC BY-SA 4.0 |