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I have a set of 10 samples, each having an unknown concentration of analyte. Each sample is quantitated by method A and method B. I need to know if the quantitative results from method A differ significantly from method B. Can I use a paired t-test for this?

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I think you might want to investigate other ways of doing this like the Bland and Altman plot which is discussed in a long and detailed answer by Stephan Kolassa in Creating and interpreting Bland-Altman plot This method has become very widely accepted in health although I do not know about other arenas.

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  • $\begingroup$ Thanks, I like the look of these plots and will try it out. $\endgroup$ – 100000eV Dec 1 '16 at 18:09
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Having a sample size of only 10, I would suggest using a non-parametric test such as the Wilcoxon signed-rank test.

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