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2 votes
2 answers
1k views

Which method of handling non-proportional hazards (here: crossed KM curves in 2+ points) would you prefer?

I have an experiment, where I compare two groups over time in frames of the time to event analysis. The Kaplan-Meier curves cross 3 times. It means, that the hazards ratios switch to the opposite side ...
OverTheRainbow's user avatar
1 vote
1 answer
436 views

Covariate and Interaction Not Significant When Both in the Model

I am looking at a survival model based on dosing variables, all of which are continuous. I have noticed when categorized, based on Kaplan Meier Curves, that low, medium, high doses behave differently, ...
JonKetchup91's user avatar
6 votes
1 answer
12k views

Interpreting interaction terms in Cox Proportional Hazard model

I am new to survival analysis, so forgive me if this questions is stupid - but I couldn't find the answer anywhere else. We are looking at readmission to a treatment program, which is defined as ...
Matthew Bowen's user avatar
5 votes
1 answer
25k views

Interaction effects in Cox model (continuous, dichotomous, and categorical variables)

I get a couple of puzzling results in my (repeated event) cox model when I introduce interaction effects. I will here pose several questions about interaction effects (in survival analysis context) in ...
FKG's user avatar
  • 300
4 votes
1 answer
413 views

Testing the proportional hazards assumption with a time varying covariate

One of the cohort studies I have carried out recently involved examining the association between post-diagnostic beta-blocker use and breast cancer outcomes in a cohort of breast cancer patients. ...
Oliver's user avatar
  • 41
2 votes
1 answer
3k views

Violation of proportional hazard for covariate but not for interaction it's part of in a Cox Proportional Hazards model

I have a problem in which one of the covariates in my model violates the assumption of proportional hazards, but the interaction it is part of does not. Data info: Lifespan - mosquito time to death (...
Aidan O'Donnell's user avatar