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Mixed effect model for repeated measurements in crossover study using R

I am trying to analyze data from a crossover study. The study has two phases and subjects are randomized to received either treatment A or Treatment B first, and then switch to the alternative ...
Kylee M's user avatar
2 votes
1 answer
356 views

Interpret results of a mixed effects model analyzing a 2x2 cross-over study?

I have conducted a randomized 2x2 cross-over trial of 8 participants measuring the effect of a specific diet (intervention) vs normal diet (control) on the number of sleep hours. The study design ...
Wandering_geek's user avatar
1 vote
0 answers
58 views

Is it normal when including an interaction effect as a fixed effect in a mixed effect model the p-value of the main effect change drastically?

I conducted a randomized crossover study in which I had two within subject factors; condition and Time. When running a repeated measures ANOVA the analysis shows significant main effect of condition ...
Methnani jabeur's user avatar
1 vote
0 answers
545 views

linear mixed model for a simple crossover trial

I would like to understand how to analyse a basic crossover trial using a linear mixed model. Participants have a baseline measure of the dependent variable, they are then randomised to either placebo ...
RobMcC's user avatar
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2 votes
0 answers
798 views

How to measure carryover effect in a crossover design 3x3?

I'm trying to analyse a potential carryover effect from a study with a crossover design 3x3, three treatments and three periods. My data has a latin square design with the treatment sequences CBA, ...
user11916948's user avatar
4 votes
0 answers
757 views

How to handle crossed and nested terms in a crossover design

Here comes my case: I conducted an experiment with the following design: 30 participants, each with a unique id, were screened and classified according to a trait. Then, all participants were tested ...
rcirer's user avatar
  • 53
1 vote
0 answers
119 views

How to analyze fractional crossover design (factional survey experiment) with 3 factors in R?

I have the following experimental design: my treatment is composed out of three factors (factor1, factor2, ...
strohne's user avatar
  • 11
2 votes
3 answers
10k views

repeated measures ANOVA, crossover trial, R

I am sorry for stating such a question. Unfortunatelly, it's very-very hard to go through all statistics. I have a crossover study design with 3 treatments, 3 periods, and a baseline (covariate). The ...
Kirill's user avatar
  • 652