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The process of randomly allocating subjects (often in the context of a clinical trial) or other experimental units into two or more conditions.

9 votes

Are the arguments that placebo can be unethical mistaken?

A randomized controlled trial requires that there is a sincere uncertainty about the relative efficacy of the treatments under investigation. The term for this uncertainty is "equipoise." The feeling …
Todd D's user avatar
  • 2,201
4 votes
Accepted

Systematic allocation of treatment: is there a chance of biasing a design?

If the randomization sequence is discovered, patients could be non randomly assigned to the experimental group of choice. In a truly blinded study, this is unlikely. In many studies, blinding may not …
Todd D's user avatar
  • 2,201
0 votes

Stratified Randomization

It would seem that requiring center stratification and allowing asymmetric enrollment are completely at odds with one another. If centers can enroll ahead of others, then center imbalance could be qui …
Todd D's user avatar
  • 2,201