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A potential perk of a placebo controlled trial would be opening the cody at the end of the study, and informing the patient of her/his actual treatment... this would amount, at least in part, to a n-of-1 trial...
@whuber My fault... Basically it's a survival analysis (Cox) including event and time to event, and testing the unadjusted and multivariable adjusted association between the variability parameter and the outcome