Brian Borchers answer is quite good---data which contain weird outliers are often not well-analyzed by OLS. I am just going to expand on this by adding a picture, a Monte Carlo, and some R code.
Consider a very simple regression model:
\begin{align}
Y_i &= \beta_1 x_i + \epsilon_i\\~\\
\epsilon_i &= \left\{\begin{array}{rcl}
N(0,0.04) &w.p. &0.999\\
31 &w.p. &0.0005\\
-31 &w.p. &0.0005 \end{array} \right.
\end{align}
This model conforms to your setup with a slope coefficient of 1.
The attached plot shows a dataset consisting of 100 observations on this model, with the x variable running from 0 to 1. In the plotted dataset, there is one draw on the error which comes up with an outlier value (+31 in this case). Also plotted are the OLS regression line in blue and the least absolute deviations regression line in red. Notice how OLS but not LAD is distorted by the outlier:
We can verify this by doing a Monte Carlo. In the Monte Carlo, I generate a dataset of 100 observations using the same $x$ and an $\epsilon$ with the above distribution 10,000 times. In those 10,000 replications, we will not get an outlier in the vast majority. But in a few we will get an outlier, and it will screw up OLS but not LAD each time. The R code below runs the Monte Carlo. Here are the results for the slope coefficients:
Mean Std Dev Minimum Maximum
Slope by OLS 1.00 0.34 -1.76 3.89
Slope by LAD 1.00 0.09 0.66 1.36
Both OLS and LAD produce unbiased estimators (the slopes are both 1.00 on average over the 10,000 replications). OLS produces an estimator with a much higher standard deviation, though, 0.34 vs 0.09. Thus, OLS is not best/most efficient among unbiased estimators, here. It's still BLUE, of course, but LAD is not linear, so there is no contradiction. Notice the wild errors OLS can make in the Min and Max column. Not so LAD.
Here is the R code for both the graph and the Monte Carlo:
# This program written in response to a Cross Validated question
# http://stats.stackexchange.com/questions/82864/when-would-least-squares-be-a-bad-idea
# The program runs a monte carlo to demonstrate that, in the presence of outliers,
# OLS may be a poor estimation method, even though it is BLUE.
library(quantreg)
library(plyr)
# Make a single 100 obs linear regression dataset with unusual error distribution
# Naturally, I played around with the seed to get a dataset which has one outlier
# data point.
set.seed(34543)
# First generate the unusual error term, a mixture of three components
e <- sqrt(0.04)*rnorm(100)
mixture <- runif(100)
e[mixture>0.9995] <- 31
e[mixture<0.0005] <- -31
summary(mixture)
summary(e)
# Regression model with beta=1
x <- 1:100 / 100
y <- x + e
# ols regression run on this dataset
reg1 <- lm(y~x)
summary(reg1)
# least absolute deviations run on this dataset
reg2 <- rq(y~x)
summary(reg2)
# plot, noticing how much the outlier effects ols and how little
# it effects lad
plot(y~x)
abline(reg1,col="blue",lwd=2)
abline(reg2,col="red",lwd=2)
# Let's do a little Monte Carlo, evaluating the estimator of the slope.
# 10,000 replications, each of a dataset with 100 observations
# To do this, I make a y vector and an x vector each one 1,000,000
# observations tall. The replications are groups of 100 in the data frame,
# so replication 1 is elements 1,2,...,100 in the data frame and replication
# 2 is 101,102,...,200. Etc.
set.seed(2345432)
e <- sqrt(0.04)*rnorm(1000000)
mixture <- runif(1000000)
e[mixture>0.9995] <- 31
e[mixture<0.0005] <- -31
var(e)
sum(e > 30)
sum(e < -30)
rm(mixture)
x <- rep(1:100 / 100, times=10000)
y <- x + e
replication <- trunc(0:999999 / 100) + 1
mc.df <- data.frame(y,x,replication)
ols.slopes <- ddply(mc.df,.(replication),
function(df) coef(lm(y~x,data=df))[2])
names(ols.slopes)[2] <- "estimate"
lad.slopes <- ddply(mc.df,.(replication),
function(df) coef(rq(y~x,data=df))[2])
names(lad.slopes)[2] <- "estimate"
summary(ols.slopes)
sd(ols.slopes$estimate)
summary(lad.slopes)
sd(lad.slopes$estimate)
