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Interaction effects in a Cox model

In regression models, usually a (descriptive) indicator of an interaction effect can be plotted via a plot with x-axis with the potential interaction variable (e.g., gender) and the outcome variable ...
Sebastian's user avatar
  • 133
2 votes
2 answers
124 views

Interpretation of Interaction when the results in one of the two groups is not statistically significant

Here is the question. Suppose we have a drug A, and we have conducted a RCT evaluating the risk of death in patients randomised to receive ...
user89547235's user avatar
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0 answers
61 views

3 terms interaction in Cox PH model

''' coxph(formula = Surv(time, hyper) ~ age + drink + smoke + sodium * tchl * BMI, data = male) coxph(formula = Surv(time, hyper) ~ age + drink + smoke + sodium * tchl * BMI, data = female) The 3-...
Nayeon's user avatar
  • 37
3 votes
2 answers
3k views

Difference in stratification, interaction and subsetting Cox Survival Regression

I'm struggling to understand the actual differences in these three approaches that came to my mind. The problem is: I want to analyze the impact of age on mortality in my cohort. However, I want to ...
user89547235's user avatar
1 vote
1 answer
106 views

If we say "Survival difference adjusted for covariates" do we mean just additive adjustment, or allow also the interactions?

Let's make it independent from any statistical package, so I will provide just numbers for the illustration. Maybe this give you some clues. I want to compare two survival curves, for group A and B. ...
CoxRegModel's user avatar
1 vote
1 answer
143 views

Presentation of a 3x3 categorical interaction for Cox proportional hazards regression using RMS package

I wanted to verify my presentation of a 3x3 interaction of two categorical variables var1 (exposure of interest) and var2 (effect modifier of interest) using the rms...
apos13's user avatar
  • 11
1 vote
1 answer
771 views

Interaction not significant in Cox regression model?

I ran a cox model with an interaction between two categorical variables (sex and treatment group) included like: ...
llbia's user avatar
  • 381
3 votes
2 answers
3k views

Why and how does adding an interaction term affects the confidence interval of a main effect?

I was wondering why, in a regression model including an interaction term, the confidence interval of one of the main effects becomes wider. Consider this Cox regression, where the variable IR_BMI27 ...
torwart's user avatar
  • 305
1 vote
1 answer
2k views

Interpretation Interaction in Cox Regression

I am estimating a discrete choice model with the help of cox regression in SPSS. I would like to interact two continuous predicting variables. The main effect of one of the ineracting variables is ...
Eva's user avatar
  • 11
2 votes
1 answer
108 views

R adds unexpected variable to interaction model

Not sure if this is more of a programming question (in which case please move to stack overflow) or a statistical model question (in which case, please read on!) I'm exploring a data set and doing ...
bdeonovic's user avatar
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1 vote
2 answers
478 views

Should I keep the interaction term?

I am doing research on mortality. I am running Cox regression and I am adjusting for 40 variables which are proven in the literature to be related with mortality. My main exposure is X. In my final ...
nani's user avatar
  • 13