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A differential equation is an equation that contains at least one derivative.

A differential equation is an equation that contains at least one derivative. A derivative is the rate of change in a function with respect to changes in a variable. For example, Newton's second law states that force equals mass times acceleration ($F = ma$), but acceleration is the rate of change in velocity over time ($a = dv/dt$), thus:
$$ F = m\frac{dv}{dt} $$