There are a range of possibilities described by J.W. Gillard in An Historical Overview
of Linear Regression with Errors in both Variables
If you are not interested in details or reasons for choosing one method over another, just go with the simplest, which is to draw the line through the centroid $(\bar{x},\bar{y})$ with slope $\hat{\beta}=s_y/s_x$, i.e. the ratio of the observed standard deviations (making the sign of the slope the same as the sign of the covariance of $x$ and $y$); as you can probably work out, this gives an intercept on the $y$-axis of $\hat{\alpha}=\bar{y}-\hat{\beta}\bar{x}.$
The merits of this particular approach are
- it gives the same line comparing $x$ against $y$ as $y$ against $x$,
- it is scale-invariant so you do not need to worry about units,
- it lies between the two ordinary linear regression lines
- it crosses them where they cross each other at the centroid of the observations, and
- it is very easy to calculate.
The slope is the geometric mean of the slopes of the two ordinary linear regression slopes. It is also what you would get if you standardised the $x$ and $y$ observations, drew a line at 45° (or 135° if there is negative correlation) and then de-standardised the line. It could also be seen as equivalent to making an implicit assumption that the variances of the two sets of errors are proportional to the variances of the two sets of observations; as far as I can tell, you claim not to know which way this is wrong.
Here is some R code to illustrate: the red line in the chart is OLS regression of $Y$ on $X$, the blue line is OLS regression of $X$ on $Y$, and the green line is this simple method. Note that the slope should be about 5.
set.seed(2011)
X0 <- 1600:3600
Y0 <- 5*X0 + 700
X1 <- X0 + 400*rnorm(2001)
Y1 <- Y0 + 2000*rnorm(2001)
slopeOLSXY <- lm(Y1 ~ X1)$coefficients[2] #OLS slope of Y on X
slopeOLSYX <- 1/lm(X1 ~ Y1)$coefficients[2] #Inverse of OLS slope of X on Y
slopesimple <- sd(Y1)/sd(X1) *sign(cov(X1,Y1)) #Simple slope
c(slopeOLSXY, slopeOLSYX, slopesimple) #Show the three slopes
# 3.408292 7.362876 5.009475
c(slopeOLSXY/cor(X1,Y1), slopeOLSYX*cor(X1,Y1), slopesimple) # adjust for cor
# 5.009475 5.009475 5.009475
plot(Y1~X1)
abline(mean(Y1) - slopeOLSXY * mean(X1), slopeOLSXY, col="red")
abline(mean(Y1) - slopeOLSYX * mean(X1), slopeOLSYX, col="blue")
abline(mean(Y1) - slopesimple * mean(X1), slopesimple, col="green")