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Use this tag for any *on-topic* question that (a) involves `R` either as a critical part of the question or expected answer, & (b) is not *just* about how to use `R`.

5 votes
2 answers
8k views

Comparing two or more treatments with inverse probablity of treatment weighting

My preference would be to conduct the analysis first using 1:1 propensity score matching, for instance using twang or MatchIt in R, or psmatch2 in Stata. … Then, confirm the main analysis without excluding any case by means of inverse probability of treatment weighting, for instance using twang in R, or meglm in Stata. …
2 votes

Diagnostic Meta-Regression with mada in R

I think your point is correct, in the sense that nominal significance is met (p=0.023) for the false positive rate (FPR), which appears positively associated with self-administered questionnaires (SAQ …
Giuseppe Biondi-Zoccai's user avatar
6 votes
1 answer
4k views

Which is the best graph to describe a survival analysis with a time-dependent covariate?

My packages of choice would be R or Stata. References Dafni U. Landmark analysis at the 25-year landmark point. Circulation: Cardiovascular Quality and Outcomes 2011;4:363-71. Ying Z, Wei LJ. … Simon R, Makuch RW. A non-parametric graphical representation of the relationship between survival and the occurrence of an event: Application to responder versus non-responder bias. …
0 votes

How to interpret heterogeneity in a meta analytic model

Egger's), which is easily performed in R with the funnel command and with the regtest command. …
Giuseppe Biondi-Zoccai's user avatar
1 vote
0 answers
222 views

Is survey analysis in Stata or R equivalent to a fixed effect generalized linear model?

I am conducting an individual patient level data meta-analysis using the survey package in R (I tried Stata 13 but I get stuck with an error). … As per meta-analytic practice, I would prefer to conduct both fixed and random effect analyses, but it appears no such option is available with the survey packages in either Stata or R. …
5 votes

multiple imputation and propensity scores

As I previously stated, instead of doing propensity matching it can be reasonable to use inverse probability of treatment weighting after missing data imputation. Suitable Stata examples follow: cle …
Giuseppe Biondi-Zoccai's user avatar
1 vote

Diagnostic accuracy meta-analysis using MADA in R

You can indeed use the mada R package, by means of the madauni command for univariate meta-analysis and the SummaryPts command for bivariate meta-analysis (the latter being recommended for instance by …
Giuseppe Biondi-Zoccai's user avatar
12 votes
1 answer
2k views

Which is the best method for network meta-analysis?

Jackson et al); hierarchical arm-based Bayesian modeling in WinBUGS (eg Zhao et al); hierarchical contrast-based (i.e. node-splitting) Bayesian modeling, either with WinBUGS or through gemtc and rjags in R … (eg White et al); network meta-analysis with lme and netmeta in R (eg Lumley, which is however limited to two-arm trials, or Rucker et al). …
1 vote
0 answers
605 views

Is mediation analysis for survival data equivalent to survival analysis with time-depent cov...

outcomes, some non-fatal which occur earlier and some fatal occurring later, I have stumbled upon mediation analysis (eg Zhang et al, Ann Transl Med 2016), which is already available in the mediation R
2 votes

How to calculate mean and standard deviation from median and quartiles

There is a detailed publication on this topic from Greco et al, How to impute study-specific standard deviations in meta-analyses of skewed continuous endpoints? World Journal of Meta-Analysis 2015;3( …
Giuseppe Biondi-Zoccai's user avatar
0 votes
0 answers
247 views

Multiple imputation for predictive analysis using mice package in R

I am using the mice package to impute some missing values, and it works nicely. I am facing a tricky strategic question though. Basically, I am working on predictors of myocardial infarction (at tim …
4 votes
1 answer
981 views

Using limited independent variables in a multivariable regression model

In particular, I am giving below an example of the dataset and the possible analysis in R (disregard the overfitting, it's just to make an example, my actual dataset has at least 10,000 cases): dep <- …
3 votes
2 answers
92 views

Appraise inconsistency (e.g. I-squared) in individual patient data meta-analysis

I am working on an individual patient data meta-analysis, using a Cox proportional hazard model, with and without taking into account study identification, in Stata and R. …
1 vote
0 answers
190 views

Most reliable method to compute 95% confidence intervals of proportions for small samples

I am planning a prospective trial for CE mark of a new cardiovascular device, and wish to use 95% confidence intervals to present, once data are collected, the inferential estimate for the occurrence …
3 votes
2 answers
3k views

Statistical analysis of relational database: is it possible and how?

I have been struggling with flat file databases and corresponding statistical packages for almost 20 years now (from Excel to SPSS, then Stata, and currently R). …

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